Changes


Last changes

On 2018-12-05:

Starting from Rhea release 99, Rhea reactions will be used in UniProt for 'Catalytic activity' annotations. See the UniProt forthcoming changes announcement for all details (upcoming UniProt release 2018_11).

Instead of having indirect links through EC numbers, starting from 2018_11 release, UniProt will provide direct links between proteins (UniProtKB entries) and Rhea reactions. These data will be searchable and downloadable from the UniProt website.

As a consequence, Rhea will stop displaying 'reactions - EC - UniProtKB/Swiss-Prot' on its public website and will no longer export them on its ftp server. On the Rhea ftp server, the biopax export files (rhea-biopax_lite.owl.gz, rhea-biopax_full.owl.gz) will be replaced by a single file: rhea-biopax.owl.gz (which does not contain any links to UniProtKB entries). The tab-separated file rhea2uniprot.tsv (via EC) will be removed.


Older changes

On 2018-01-31:

In Rhea release 90, the participants on each side of the reactions are sorted alphabetically (ascii, case insensitive).

Old data:
RHEA:21732 L-glutamine + chorismate = L-glutamate + anthranilate + H(+) + pyruvate

New data:
RHEA:21732 chorismate + L-glutamine = anthranilate + H(+) + L-glutamate + pyruvate

This affects the web page, the REST web services and the ftp downloads.

On 2017-11-22:

In Rhea release 88, the cross references from Rhea reactions to EC numbers have been moved from bidirectional Rhea reactions (<=>) to Rhea reactions with undefined direction (=) (also called "master" reactions)

Old data:
RHEA:10739 a primary alcohol + NAD(+) <=> an aldehyde + H(+) + NADH
Cross reference: EC 1.1.1.1

New data:
RHEA:10736 a primary alcohol + NAD(+) = an aldehyde + H(+) + NADH
Cross reference: EC 1.1.1.1

This affects the web page, the REST web services and the ftp downloads. The file ec-rhea-dir.tsv have been removed from the ftp. The files rhea-ec-iubmb.tsv and rhea2ec.tsv remain.

On 2017-08-30:

In Rhea release 85, the separator in reactions with undefined direction ("master" reactions) has been changed from "<?>" to the equals sign "=".

Old format: A + B <?> C + D
New format: A + B = C + D

This affects the web page, the REST web services and the ftp downloads.