RHEA:10191          (APPROVED)

acetoacetyl-CoA + acetyl-CoA + H2O <=> (3S)-hydroxy-3-methylglutaryl-CoA + CoA + H(+)

Last modified: 2019-05-24. Chemically balanced: yes.

acetoacetyl-CoA
CHEBI:57286
chebi link
Formula: C25H36N7O18P3S
Charge: -4
(no structure available)
+
acetyl-CoA
CHEBI:57288
chebi link
Formula: C23H34N7O17P3S
Charge: -4
(no structure available)
+
H2O
CHEBI:15377
chebi link
Formula: H2O
Charge: 0
(no structure available)
<=>
(3S)-hydroxy-3-methylglutaryl-CoA
CHEBI:43074
chebi link
Formula: C27H39N7O20P3S
Charge: -5
(no structure available)
+
CoA
CHEBI:57287
chebi link
Formula: C21H32N7O16P3S
Charge: -4
(no structure available)
+
H+
CHEBI:15378
chebi link
Formula: H
Charge: 1
(no structure available)

Same participants, different directions

RHEA:10188 acetoacetyl-CoA + acetyl-CoA + H2O = (3S)-hydroxy-3-methylglutaryl-CoA + CoA + H(+)
RHEA:10189 acetoacetyl-CoA + acetyl-CoA + H2O => (3S)-hydroxy-3-methylglutaryl-CoA + CoA + H(+)
RHEA:10190 (3S)-hydroxy-3-methylglutaryl-CoA + CoA + H(+) => acetoacetyl-CoA + acetyl-CoA + H2O

Links to other resources

Enzymes
Enzyme classification
EC 2.3.3.10  [ENZYME]  [IntEnz]
UniProtKB
 [reviewed protein(s)]  [all proteins(s)]
Reactions
KEGG reaction
R01978
MetaCyc
HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN

Reaction relationships

Outgoing
no data
Incoming
no data

Citations

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