RHEA:10584          (APPROVED)

4-coumaroyl-CoA + 3 H(+) + 3 malonyl-CoA + NADPH = 3 CO2 + 4 CoA + H2O + isoliquiritigenin + NADP(+)

Last modified: 2019-11-04. Chemically balanced: yes.

4-coumaroyl-CoA
CHEBI:57355
chebi link
Formula: C30H38N7O18P3S
Charge: -4
(no structure available)
+
3
H+
CHEBI:15378
chebi link
Formula: H
Charge: 1
(no structure available)
+
3
malonyl-CoA
CHEBI:57384
chebi link
Formula: C24H33N7O19P3S
Charge: -5
(no structure available)
+
NADPH
CHEBI:57783
chebi link
Formula: C21H26N7O17P3
Charge: -4
(no structure available)
=
3
CO2
CHEBI:16526
chebi link
Formula: CO2
Charge: 0
(no structure available)
+
4
CoA
CHEBI:57287
chebi link
Formula: C21H32N7O16P3S
Charge: -4
(no structure available)
+
H2O
CHEBI:15377
chebi link
Formula: H2O
Charge: 0
(no structure available)
+
isoliquiritigenin
CHEBI:77948
chebi link
Formula: C15H11O4
Charge: -1
(no structure available)
+
NADP+
CHEBI:58349
chebi link
Formula: C21H25N7O17P3
Charge: -3
(no structure available)

Same participants, different directions

RHEA:10585 4-coumaroyl-CoA + 3 H(+) + 3 malonyl-CoA + NADPH => 3 CO2 + 4 CoA + H2O + isoliquiritigenin + NADP(+)
RHEA:10586 3 CO2 + 4 CoA + H2O + isoliquiritigenin + NADP(+) => 4-coumaroyl-CoA + 3 H(+) + 3 malonyl-CoA + NADPH
RHEA:10587 4-coumaroyl-CoA + 3 H(+) + 3 malonyl-CoA + NADPH <=> 3 CO2 + 4 CoA + H2O + isoliquiritigenin + NADP(+)

Links to other resources

Enzymes
Enzyme classification
EC 2.3.1.170  [ENZYME]  [IntEnz]
UniProtKB
 [reviewed protein(s)]  [all proteins(s)]
Reactions
KEGG reaction
R06568
MetaCyc
RXN-3142

Reaction relationships

Outgoing
no data
Incoming
no data

Citations

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