RHEA:10590          (APPROVED)

4 CO2 + 4 CoA + 4 H2O + 8 NADP(+) + tetramethylated-mycocerosoyl-[mycocerosate synthase] => 4 (R)-methylmalonyl-CoA + 12 H(+) + long-chain acyl-[mycocerosate synthase] + 8 NADPH

Last modified: 2020-05-18. Chemically balanced: yes. Qualifiers: Class of reactions

4
(R)-methylmalonyl-CoA
CHEBI:57326
chebi link
Formula: C25H35N7O19P3S
Charge: -5
(no structure available)
+
12
H+
CHEBI:15378
chebi link
Formula: H
Charge: 1
(no structure available)
+
long-chain acyl-[mycocerosate synthase]
GENERIC:13239
(RHEA-COMP:13239)
(no structure available)
O-(S-[long-chain fatty acyl]pantetheine-4'-phosphoryl)serine residue
CHEBI:133243
chebi link
Formula: C15H24N3O9PSR
Charge: -1
Position: 
+
8
NADPH
CHEBI:57783
chebi link
Formula: C21H26N7O17P3
Charge: -4
(no structure available)
<=
4
CO2
CHEBI:16526
chebi link
Formula: CO2
Charge: 0
(no structure available)
+
4
CoA
CHEBI:57287
chebi link
Formula: C21H32N7O16P3S
Charge: -4
(no structure available)
+
4
H2O
CHEBI:15377
chebi link
Formula: H2O
Charge: 0
(no structure available)
+
8
NADP+
CHEBI:58349
chebi link
Formula: C21H25N7O17P3
Charge: -3
(no structure available)
+
tetramethylated-mycocerosoyl-[mycocerosate synthase]
GENERIC:12642
(RHEA-COMP:12642)
(no structure available)
O-(S-[2R,4R,6R,8R]-2,4,6,8-tetramethyl-very-long-chain fatty acyl-pantetheine-4'-phosphoryl)serine residue
CHEBI:132569
chebi link
Formula: C27H48N3O9PSR
Charge: -1
Position: 

Same participants, different directions

RHEA:10588 4 (R)-methylmalonyl-CoA + 12 H(+) + long-chain acyl-[mycocerosate synthase] + 8 NADPH = 4 CO2 + 4 CoA + 4 H2O + 8 NADP(+) + tetramethylated-mycocerosoyl-[mycocerosate synthase]
RHEA:10589 4 (R)-methylmalonyl-CoA + 12 H(+) + long-chain acyl-[mycocerosate synthase] + 8 NADPH => 4 CO2 + 4 CoA + 4 H2O + 8 NADP(+) + tetramethylated-mycocerosoyl-[mycocerosate synthase]
RHEA:10591 4 (R)-methylmalonyl-CoA + 12 H(+) + long-chain acyl-[mycocerosate synthase] + 8 NADPH <=> 4 CO2 + 4 CoA + 4 H2O + 8 NADP(+) + tetramethylated-mycocerosoyl-[mycocerosate synthase]

Links to other resources

Enzymes
Enzyme classification
EC 2.3.1.111  [ENZYME]  [IntEnz]
UniProtKB
 [reviewed protein(s)]  [all proteins(s)]
Reactions
MetaCyc
MYCOCEROSATE-SYNTHASE-RXN

Reaction relationships

Outgoing
no data
Incoming
no data

Citations

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