RHEA:12240          (APPROVED)

acetyl-CoA + 3 H(+) + 3 malonyl-CoA + NADPH = 6-methylsalicylate + 3 CO2 + 4 CoA + H2O + NADP(+)

Last modified: 2020-05-27. Chemically balanced: yes.

acetyl-CoA
CHEBI:57288
chebi link
Formula: C23H34N7O17P3S
Charge: -4
(no structure available)
+
3
H+
CHEBI:15378
chebi link
Formula: H
Charge: 1
(no structure available)
+
3
malonyl-CoA
CHEBI:57384
chebi link
Formula: C24H33N7O19P3S
Charge: -5
(no structure available)
+
NADPH
CHEBI:57783
chebi link
Formula: C21H26N7O17P3
Charge: -4
(no structure available)
=
6-methylsalicylate
CHEBI:36658
chebi link
Formula: C8H7O3
Charge: -1
(no structure available)
+
3
CO2
CHEBI:16526
chebi link
Formula: CO2
Charge: 0
(no structure available)
+
4
CoA
CHEBI:57287
chebi link
Formula: C21H32N7O16P3S
Charge: -4
(no structure available)
+
H2O
CHEBI:15377
chebi link
Formula: H2O
Charge: 0
(no structure available)
+
NADP+
CHEBI:58349
chebi link
Formula: C21H25N7O17P3
Charge: -3
(no structure available)

Same participants, different directions

RHEA:12241 acetyl-CoA + 3 H(+) + 3 malonyl-CoA + NADPH => 6-methylsalicylate + 3 CO2 + 4 CoA + H2O + NADP(+)
RHEA:12242 6-methylsalicylate + 3 CO2 + 4 CoA + H2O + NADP(+) => acetyl-CoA + 3 H(+) + 3 malonyl-CoA + NADPH
RHEA:12243 acetyl-CoA + 3 H(+) + 3 malonyl-CoA + NADPH <=> 6-methylsalicylate + 3 CO2 + 4 CoA + H2O + NADP(+)

Links to other resources

Enzymes
Enzyme classification
EC 2.3.1.165  [ENZYME]  [IntEnz]
UniProtKB
 [reviewed protein(s)]  [all proteins(s)]
Reactions
KEGG reaction
R07253
MetaCyc
2.3.1.165-RXN

Reaction relationships

Outgoing
no data
Incoming
no data

Citations

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