RHEA:12390          (APPROVED)

2'-hydroxyformononetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => formononetin + O2 + reduced [NADPH--hemoprotein reductase]

Last modified: 2018-04-23. Chemically balanced: yes.

formononetin
CHEBI:77688
chebi link
Formula: C16H11O4
Charge: -1
(no structure available)
+
O2
CHEBI:15379
chebi link
Formula: O2
Charge: 0
(no structure available)
+
reduced [NADPH—hemoprotein reductase]
GENERIC:11964
(RHEA-COMP:11964)
(no structure available)
FMNH2
CHEBI:57618
chebi link
Formula: C17H21N4O9P
Charge: -2
Position: 
<=
2'-hydroxyformononetin
CHEBI:77687
chebi link
Formula: C16H11O5
Charge: -1
(no structure available)
+
H+
CHEBI:15378
chebi link
Formula: H
Charge: 1
(no structure available)
+
H2O
CHEBI:15377
chebi link
Formula: H2O
Charge: 0
(no structure available)
+
oxidized [NADPH—hemoprotein reductase]
GENERIC:11965
(RHEA-COMP:11965)
(no structure available)
FMN
CHEBI:58210
chebi link
Formula: C17H18N4O9P
Charge: -3
Position: 

Same participants, different directions

RHEA:12388 formononetin + O2 + reduced [NADPH--hemoprotein reductase] = 2'-hydroxyformononetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:12389 formononetin + O2 + reduced [NADPH--hemoprotein reductase] => 2'-hydroxyformononetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:12391 formononetin + O2 + reduced [NADPH--hemoprotein reductase] <=> 2'-hydroxyformononetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]

Comments

Published in: Hinderer, W., Flentje, U. and Barz, W. Microsomal isoflavone 2′-hydroxylases and 3′-hydroxylases from chickpea (Cicer arietinum L) cell-suspensions induced for pterocarpan phytoalexin formation. FEBS Lett. 214 (1987) 101–106.

Links to other resources

Enzymes
Enzyme classification
EC 1.14.14.89  [ENZYME]  [IntEnz]
Enzyme classification
EC 1.14.14.90  [ENZYME]  [IntEnz]
UniProtKB
 [reviewed protein(s)]  [all proteins(s)]
Reactions
KEGG reaction
R06560
MetaCyc
ISOFLAVONE-2-HYDROXYLASE-RXN

Reaction relationships

Outgoing
RHEA:12390
is a
RHEA:18851
a 2'-hydroxyisoflavone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => a 2'-unsubstituted isoflavone + O2 + reduced [NADPH--hemoprotein reductase]
Incoming
no data

Citations

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