RHEA:12766          (APPROVED)

CoA + 2 oxidized [2Fe-2S]-[ferredoxin] + pyruvate => acetyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]

Last modified: 2019-12-09. Chemically balanced: yes.

CoA
CHEBI:57287
chebi link
Formula: C21H32N7O16P3S
Charge: -4
(no structure available)
+
2
oxidized [2Fe-2S]-[ferredoxin]
GENERIC:10000
(RHEA-COMP:10000)
(no structure available)
[2Fe-2S]2+
CHEBI:33737
chebi link
Formula: Fe2S2
Charge: 2
Position: 
+
pyruvate
CHEBI:15361
chebi link
Formula: C3H3O3
Charge: -1
(no structure available)
=>
acetyl-CoA
CHEBI:57288
chebi link
Formula: C23H34N7O17P3S
Charge: -4
(no structure available)
+
CO2
CHEBI:16526
chebi link
Formula: CO2
Charge: 0
(no structure available)
+
H+
CHEBI:15378
chebi link
Formula: H
Charge: 1
(no structure available)
+
2
reduced [2Fe-2S]-[ferredoxin]
GENERIC:10001
(RHEA-COMP:10001)
(no structure available)
[2Fe-2S]1+
CHEBI:33738
chebi link
Formula: Fe2S2
Charge: 1
Position: 

Same participants, different directions

RHEA:12765 CoA + 2 oxidized [2Fe-2S]-[ferredoxin] + pyruvate = acetyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]
RHEA:12767 acetyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => CoA + 2 oxidized [2Fe-2S]-[ferredoxin] + pyruvate
RHEA:12768 CoA + 2 oxidized [2Fe-2S]-[ferredoxin] + pyruvate <=> acetyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]

Links to other resources

Enzymes
Enzyme classification
EC 1.2.7.1  [ENZYME]  [IntEnz]
UniProtKB
 [reviewed protein(s)]  [all proteins(s)]
Reactions
KEGG reaction
R01196
EcoCyc
PYRUFLAVREDUCT-RXN
MetaCyc
PYRUFLAVREDUCT-RXN

Reaction relationships

Outgoing
RHEA:12766
is a
RHEA:42317
a 2-oxocarboxylate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] => an acyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]
Incoming
no data

Citations

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