RHEA:13458          (APPROVED)

3-methyl-2-oxobutanoate + [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase]-(R)-N(6)-lipoyl-L-lysine + H(+) => [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase]-(R)-N(6)-(S(8)-2-methylpropanoyldihydrolipoyl)-L-lysine + CO2

Last modified: 2014-10-22. Chemically balanced: yes.

3-methyl-2-oxobutanoate
CHEBI:11851
chebi link
Formula: C5H7O3
Charge: -1
(no structure available)
+
[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase]-(R)-N6-lipoyl-L-lysine
GENERIC:10488
(RHEA-COMP:10488)
(no structure available)
(R)-N6-lipoyl-L-lysine residue
CHEBI:83099
chebi link
Formula: C14H24N2O2S2
Charge: 0
Position: 
+
H+
CHEBI:15378
chebi link
Formula: H
Charge: 1
(no structure available)
=>
[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase]-(R)-N6-(S8-2-methylpropanoyldihydrolipoyl)-L-lysine
GENERIC:10489
(RHEA-COMP:10489)
(no structure available)
(R)-N6-(S8-2-methylpropanoyldihydrolipoyl)-L-lysine residue
CHEBI:83142
chebi link
Formula: C18H32N2O3S2
Charge: 0
Position: 
+
CO2
CHEBI:16526
chebi link
Formula: CO2
Charge: 0
(no structure available)

Same participants, different directions

RHEA:13457 3-methyl-2-oxobutanoate + [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase]-(R)-N(6)-lipoyl-L-lysine + H(+) = [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase]-(R)-N(6)-(S(8)-2-methylpropanoyldihydrolipoyl)-L-lysine + CO2
RHEA:13459 [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase]-(R)-N(6)-(S(8)-2-methylpropanoyldihydrolipoyl)-L-lysine + CO2 => 3-methyl-2-oxobutanoate + [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase]-(R)-N(6)-lipoyl-L-lysine + H(+)
RHEA:13460 3-methyl-2-oxobutanoate + [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase]-(R)-N(6)-lipoyl-L-lysine + H(+) <=> [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase]-(R)-N(6)-(S(8)-2-methylpropanoyldihydrolipoyl)-L-lysine + CO2

Links to other resources

Enzymes
Enzyme classification
EC 1.2.4.4  [ENZYME]  [IntEnz]
UniProtKB
 [reviewed protein(s)]  [all proteins(s)]
Reactions
KEGG reaction
R01701
MetaCyc
1.2.4.4-RXN

Reaction relationships

Outgoing
no data
Incoming
no data

Citations

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