RHEA:15421          (APPROVED)

a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate

Last modified: 2020-04-08. Chemically balanced: yes. Qualifiers: Class of reactions

a long-chain fatty acid
CHEBI:57560
chebi link
Formula: CO2R
Charge: -1
(no structure available)
+
ATP
CHEBI:30616
chebi link
Formula: C10H12N5O13P3
Charge: -4
(no structure available)
+
CoA
CHEBI:57287
chebi link
Formula: C21H32N7O16P3S
Charge: -4
(no structure available)
=
a long-chain fatty acyl-CoA
CHEBI:83139
chebi link
Formula: C22H31N7O17P3SR
Charge: -4
(no structure available)
+
AMP
CHEBI:456215
chebi link
Formula: C10H12N5O7P
Charge: -2
(no structure available)
+
diphosphate
CHEBI:33019
chebi link
Formula: HO7P2
Charge: -3
(no structure available)

Same participants, different directions

RHEA:15422 a long-chain fatty acid + ATP + CoA => a long-chain fatty acyl-CoA + AMP + diphosphate
RHEA:15423 a long-chain fatty acyl-CoA + AMP + diphosphate => a long-chain fatty acid + ATP + CoA
RHEA:15424 a long-chain fatty acid + ATP + CoA <=> a long-chain fatty acyl-CoA + AMP + diphosphate

Links to other resources

Enzymes
Enzyme classification
EC 6.2.1.3  [ENZYME]  [IntEnz]
UniProtKB
 [reviewed protein(s)]  [all proteins(s)]
Reactions
KEGG reaction
R00390
MetaCyc
RXN-7904

Reaction relationships

Outgoing
RHEA:15421
is a
RHEA:38883
a fatty acid + ATP + CoA = a fatty acyl-CoA + AMP + diphosphate
Incoming
RHEA:30751
ATP + CoA + hexadecanoate = AMP + diphosphate + hexadecanoyl-CoA
is a
RHEA:15421
RHEA:33607
(9Z)-octadecenoate + ATP + CoA = (9Z)-octadecenoyl-CoA + AMP + diphosphate
is a
RHEA:15421
RHEA:33615
ATP + CoA + octadecanoate = AMP + diphosphate + octadecanoyl-CoA
is a
RHEA:15421
RHEA:33619
ATP + CoA + tetradecanoate = AMP + diphosphate + tetradecanoyl-CoA
is a
RHEA:15421
RHEA:33635
ATP + CoA + docosanoate = AMP + diphosphate + docosanoyl-CoA
is a
RHEA:15421
RHEA:33643
(9Z)-tetradecenoate + ATP + CoA = (9Z)-tetradecenoyl-CoA + AMP + diphosphate
is a
RHEA:15421
RHEA:33647
(9Z)-hexadecenoate + ATP + CoA = (9Z)-hexadecenoyl-CoA + AMP + diphosphate
is a
RHEA:15421
RHEA:33651
(9Z,12Z)-octadecadienoate + ATP + CoA = (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate
is a
RHEA:15421
RHEA:36139
(E)-hexadec-2-enoate + ATP + CoA = (2E)-hexadecenoyl-CoA + AMP + diphosphate
is a
RHEA:15421
RHEA:44076
ATP + CoA + pentadecanoate = AMP + diphosphate + pentadecanoyl-CoA
is a
RHEA:15421
RHEA:44084
ATP + CoA + heptadecanoate = AMP + diphosphate + heptadecanoyl-CoA
is a
RHEA:15421
RHEA:44092
ATP + CoA + nonadecanoate = AMP + diphosphate + nonadecanoyl-CoA
is a
RHEA:15421
RHEA:44192
2-methylhexadecanoate + ATP + CoA = 2-methylhexadecanoyl-CoA + AMP + diphosphate
is a
RHEA:15421
RHEA:44200
12-methyloctadecanoate + ATP + CoA = 12-methyloctadecanoyl-CoA + AMP + diphosphate
is a
RHEA:15421
RHEA:44204
2-hydroxyhexadecanoate + ATP + CoA = 2-hydroxyhexadecanoyl-CoA + AMP + diphosphate
is a
RHEA:15421
RHEA:44208
12-methyltridecanoate + ATP + CoA = 12-methyltridecanoyl-CoA + AMP + diphosphate
is a
RHEA:15421
RHEA:44212
3-hydroxytetradecanoate + ATP + CoA = 3-hydroxytetradecanoyl-CoA + AMP + diphosphate
is a
RHEA:15421
RHEA:44216
12-hydroxyoctadecanoate + ATP + CoA = 12-hydroxyoctadecanoyl-CoA + AMP + diphosphate
is a
RHEA:15421
RHEA:44220
15-hydroxypentadecanoate + ATP + CoA = 15-hydroxypentadecanoyl-CoA + AMP + diphosphate
is a
RHEA:15421
RHEA:44936
(9Z,12Z,15Z)-octadecatrienoate + ATP + CoA = (9Z,12Z,15Z)-octadecatrienoyl-CoA + AMP + diphosphate
is a
RHEA:15421
RHEA:46208
ATP + CoA + eicosanoate = AMP + diphosphate + eicosanoyl-CoA
is a
RHEA:15421
RHEA:52008
8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + ATP + CoA = 8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoyl-CoA + AMP + diphosphate
is a
RHEA:15421
RHEA:52012
11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + ATP + CoA = 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoyl-CoA + AMP + diphosphate
is a
RHEA:15421
RHEA:52016
14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + ATP + CoA = 14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoyl-CoA + AMP + diphosphate
is a
RHEA:15421
RHEA:52112
12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + ATP + CoA = 12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate
is a
RHEA:15421

Citations

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