RHEA:15992          (APPROVED)

(R)-mevalonate + CoA + 2 NADP(+) <=> (3S)-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADPH

Last modified: 2019-05-24. Chemically balanced: yes.

(R)-mevalonate
CHEBI:36464
chebi link
Formula: C6H11O4
Charge: -1
(no structure available)
+
CoA
CHEBI:57287
chebi link
Formula: C21H32N7O16P3S
Charge: -4
(no structure available)
+
2
NADP+
CHEBI:58349
chebi link
Formula: C21H25N7O17P3
Charge: -3
(no structure available)
<=>
(3S)-hydroxy-3-methylglutaryl-CoA
CHEBI:43074
chebi link
Formula: C27H39N7O20P3S
Charge: -5
(no structure available)
+
2
H+
CHEBI:15378
chebi link
Formula: H
Charge: 1
(no structure available)
+
2
NADPH
CHEBI:57783
chebi link
Formula: C21H26N7O17P3
Charge: -4
(no structure available)

Same participants, different directions

RHEA:15989 (R)-mevalonate + CoA + 2 NADP(+) = (3S)-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADPH
RHEA:15990 (R)-mevalonate + CoA + 2 NADP(+) => (3S)-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADPH
RHEA:15991 (3S)-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADPH => (R)-mevalonate + CoA + 2 NADP(+)

Links to other resources

Enzymes
Enzyme classification
EC 1.1.1.34  [ENZYME]  [IntEnz]
UniProtKB
 [reviewed protein(s)]  [all proteins(s)]
Reactions
KEGG reaction
R02082
MetaCyc
1.1.1.34-RXN
MACiE
M0093
Reactome
R-HSA-191352.1

Reaction relationships

Outgoing
no data
Incoming
no data

Citations

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