RHEA:16303          (APPROVED)

ADP-D-ribose + H(+) + nicotinamide => H2O + NAD(+)

Last modified: 2019-03-04. Chemically balanced: yes.

H2O
CHEBI:15377
chebi link
Formula: H2O
Charge: 0
(no structure available)
+
NAD+
CHEBI:57540
chebi link
Formula: C21H26N7O14P2
Charge: -1
(no structure available)
<=
ADP-D-ribose
CHEBI:57967
chebi link
Formula: C15H21N5O14P2
Charge: -2
(no structure available)
+
H+
CHEBI:15378
chebi link
Formula: H
Charge: 1
(no structure available)
+
nicotinamide
CHEBI:17154
chebi link
Formula: C6H6N2O
Charge: 0
(no structure available)

Same participants, different directions

RHEA:16301 H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide
RHEA:16302 H2O + NAD(+) => ADP-D-ribose + H(+) + nicotinamide
RHEA:16304 H2O + NAD(+) <=> ADP-D-ribose + H(+) + nicotinamide

Comments

Multi-step reaction (EC 3.2.2.6 only): RHEA:38611 and RHEA:38615

EC 3.2.2.5 catalyses the hydrolysis of NAD+, without associated ADP-ribosyl cyclase activity (unlike enzyme EC 3.2.2.6, bifunctional ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase).

Links to other resources

Enzymes
Enzyme classification
EC 3.2.2.5  [ENZYME]  [IntEnz]
Enzyme classification
EC 3.2.2.6  [ENZYME]  [IntEnz]
UniProtKB
 [reviewed protein(s)]  [all proteins(s)]
Reactions
KEGG reaction
R00102
MetaCyc
NADNUCLEOSID-RXN
Reactome
R-HSA-8870346.2
Reactome
R-HSA-8938076.1

Reaction relationships

Outgoing
no data
Incoming
no data

Citations

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