RHEA:16585          (APPROVED)

[[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + 4 H(+) + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + 2 5'-deoxyadenosine + [[Fe-S] cluster scaffold protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin]

Last modified: 2019-12-09. Chemically balanced: yes.

[[Fe-S] cluster scaffold protein carrying a second [4Fe-4S]2+ cluster]
GENERIC:14568
(RHEA-COMP:14568)
(no structure available)
[4Fe-4S]2+ cluster
CHEBI:33722
chebi link
Formula: Fe4S4
Charge: 2
Position: A
(no structure available)
[4Fe-4S]2+ cluster
CHEBI:33722
chebi link
Formula: Fe4S4
Charge: 2
Position: B
+
4
H+
CHEBI:15378
chebi link
Formula: H
Charge: 1
(no structure available)
+
N6-octanoyl-L-lysyl-[protein]
GENERIC:9928
(RHEA-COMP:9928)
(no structure available)
N6-octanoyl-L-lysine residue
CHEBI:78809
chebi link
Formula: C14H26N2O2
Charge: 0
Position: 
+
2
oxidized [2Fe-2S]-[ferredoxin]
GENERIC:10000
(RHEA-COMP:10000)
(no structure available)
[2Fe-2S]2+
CHEBI:33737
chebi link
Formula: Fe2S2
Charge: 2
Position: 
+
2
S-adenosyl-L-methionine
CHEBI:59789
chebi link
Formula: C15H23N6O5S
Charge: 1
(no structure available)
=
(R)-N6-dihydrolipoyl-L-lysyl-[protein]
GENERIC:10475
(RHEA-COMP:10475)
(no structure available)
(R)-N6-dihydrolipoyl-L-lysine residue
CHEBI:83100
chebi link
Formula: C14H26N2O2S2
Charge: 0
Position: 
+
2
5'-deoxyadenosine
CHEBI:17319
chebi link
Formula: C10H13N5O3
Charge: 0
(no structure available)
+
[[Fe-S] cluster scaffold protein]
GENERIC:14569
(RHEA-COMP:14569)
(no structure available)
[4Fe-4S]2+ cluster
CHEBI:33722
chebi link
Formula: Fe4S4
Charge: 2
Position: A
+
4
Fe3+
CHEBI:29034
chebi link
Formula: Fe
Charge: 3
(no structure available)
+
2
hydrogen sulfide
CHEBI:29919
chebi link
Formula: HS
Charge: -1
(no structure available)
+
2
L-methionine
CHEBI:57844
chebi link
Formula: C5H11NO2S
Charge: 0
(no structure available)
+
2
reduced [2Fe-2S]-[ferredoxin]
GENERIC:10001
(RHEA-COMP:10001)
(no structure available)
[2Fe-2S]1+
CHEBI:33738
chebi link
Formula: Fe2S2
Charge: 1
Position: 

Same participants, different directions

RHEA:16586 [[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + 4 H(+) + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine => (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + 2 5'-deoxyadenosine + [[Fe-S] cluster scaffold protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin]
RHEA:16587 (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + 2 5'-deoxyadenosine + [[Fe-S] cluster scaffold protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin] => [[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + 4 H(+) + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine
RHEA:16588 [[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + 4 H(+) + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine <=> (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + 2 5'-deoxyadenosine + [[Fe-S] cluster scaffold protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin]

Links to other resources

Enzymes
Enzyme classification
EC 2.8.1.8  [ENZYME]  [IntEnz]
UniProtKB
 [reviewed protein(s)]  [all proteins(s)]
Reactions
KEGG reaction
R07767
EcoCyc
RXN0-949
MetaCyc
RXN0-949

Reaction relationships

Outgoing
no data
Incoming
no data

Citations

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