RHEA:16873          (APPROVED)

(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH + uridine(54) in tRNA = (6S)-5,6,7,8-tetrahydrofolate + 5-methyluridine(54) in tRNA + NAD(+)

Last modified: 2020-05-27. Chemically balanced: yes.

(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate
CHEBI:15636
chebi link
Formula: C20H21N7O6
Charge: -2
(no structure available)
+
H+
CHEBI:15378
chebi link
Formula: H
Charge: 1
(no structure available)
+
NADH
CHEBI:57945
chebi link
Formula: C21H27N7O14P2
Charge: -2
(no structure available)
+
uridine54 in tRNA
GENERIC:10193
(RHEA-COMP:10193)
(no structure available)
UMP residue
CHEBI:65315
chebi link
Formula: C9H10N2O8P
Charge: -1
Position: 54
=
(6S)-5,6,7,8-tetrahydrofolate
CHEBI:57453
chebi link
Formula: C19H21N7O6
Charge: -2
(no structure available)
+
5-methyluridine54 in tRNA
GENERIC:10167
(RHEA-COMP:10167)
(no structure available)
5-methyluridine 5'-phosphate residue
CHEBI:74447
chebi link
Formula: C10H12N2O8P
Charge: -1
Position: 54
+
NAD+
CHEBI:57540
chebi link
Formula: C21H26N7O14P2
Charge: -1
(no structure available)

Same participants, different directions

RHEA:16874 (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH + uridine(54) in tRNA => (6S)-5,6,7,8-tetrahydrofolate + 5-methyluridine(54) in tRNA + NAD(+)
RHEA:16875 (6S)-5,6,7,8-tetrahydrofolate + 5-methyluridine(54) in tRNA + NAD(+) => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH + uridine(54) in tRNA
RHEA:16876 (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH + uridine(54) in tRNA <=> (6S)-5,6,7,8-tetrahydrofolate + 5-methyluridine(54) in tRNA + NAD(+)

Links to other resources

Enzymes
Enzyme classification
EC 2.1.1.74  [ENZYME]  [IntEnz]
UniProtKB
 [reviewed protein(s)]  [all proteins(s)]
Reactions
KEGG reaction
R03704
MetaCyc
2.1.1.74-RXN

Reaction relationships

Outgoing
no data
Incoming
no data

Citations

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