RHEA:19817          (APPROVED)

(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NADP(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH

Last modified: 2020-02-03. Chemically balanced: yes.

(6S)-5-methyl-5,6,7,8-tetrahydrofolate
CHEBI:18608
chebi link
Formula: C20H23N7O6
Charge: -2
(no structure available)
+
NADP+
CHEBI:58349
chebi link
Formula: C21H25N7O17P3
Charge: -3
(no structure available)
=
(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate
CHEBI:15636
chebi link
Formula: C20H21N7O6
Charge: -2
(no structure available)
+
H+
CHEBI:15378
chebi link
Formula: H
Charge: 1
(no structure available)
+
NADPH
CHEBI:57783
chebi link
Formula: C21H26N7O17P3
Charge: -4
(no structure available)

Same participants, different directions

RHEA:19818 (6S)-5-methyl-5,6,7,8-tetrahydrofolate + NADP(+) => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH
RHEA:19819 (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH => (6S)-5-methyl-5,6,7,8-tetrahydrofolate + NADP(+)
RHEA:19820 (6S)-5-methyl-5,6,7,8-tetrahydrofolate + NADP(+) <=> (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH

Links to other resources

Enzymes
Enzyme classification
EC 1.5.1.20  [ENZYME]  [IntEnz]
UniProtKB
 [reviewed protein(s)]  [all proteins(s)]
Reactions
KEGG reaction
R01224
MACiE
M0120

Reaction relationships

Outgoing
no data
Incoming
no data

Citations

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