RHEA:32627          (APPROVED)

(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 2 NADP(+) = 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 H(+) + 2 NADPH

Last modified: 2020-04-08. Chemically balanced: yes.

(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin
CHEBI:59560
chebi link
Formula: C9H15N5O3
Charge: 0
(no structure available)
+
2
NADP+
CHEBI:58349
chebi link
Formula: C21H25N7O17P3
Charge: -3
(no structure available)
=
6-pyruvoyl-5,6,7,8-tetrahydropterin
CHEBI:136564
chebi link
Formula: C9H11N5O3
Charge: 0
(no structure available)
+
2
H+
CHEBI:15378
chebi link
Formula: H
Charge: 1
(no structure available)
+
2
NADPH
CHEBI:57783
chebi link
Formula: C21H26N7O17P3
Charge: -4
(no structure available)

Same participants, different directions

RHEA:32628 (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 2 NADP(+) => 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 H(+) + 2 NADPH
RHEA:32629 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 H(+) + 2 NADPH => (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 2 NADP(+)
RHEA:32630 (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 2 NADP(+) <=> 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 H(+) + 2 NADPH

Comments

Multi-step reaction: RHEA:42500 and RHEA:11772

Links to other resources

Enzymes
Enzyme classification
EC 1.1.1.153  [ENZYME]  [IntEnz]
UniProtKB
 [reviewed protein(s)]  [all proteins(s)]
Reactions
KEGG reaction
R08208
MetaCyc
RXN-8853

Reaction relationships

Outgoing
RHEA:32627
is a
RHEA:24738
(6R)-5,6,7,8-tetrahydrobiopterin + 2 NADP(+) = 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 H(+) + 2 NADPH
Incoming
no data

Citations

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