Enzymes
| UniProtKB help_outline | 2 proteins |
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- Name help_outline 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine Identifier CHEBI:74986 Charge 0 Formula C41H78NO8P InChIKeyhelp_outline MWRBNPKJOOWZPW-NYVOMTAGSA-N SMILEShelp_outline O(C(=O)CCCCCCC/C=C\CCCCCCCC)[C@H](COC(=O)CCCCCCC/C=C\CCCCCCCC)COP(=O)([O-])OCC[NH3+] 2D coordinates Mol file for the small molecule Search links Involved in 15 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine Identifier CHEBI:73000 Charge 0 Formula C42H84NO8P InChIKeyhelp_outline PZNPLUBHRSSFHT-RRHRGVEJSA-N SMILEShelp_outline [H][C@@](COC(=O)CCCCCCCCCCCCCCC)(COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCCCC 2D coordinates Mol file for the small molecule Search links Involved in 5 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline 2-octadecanoyl-sn-glycero-3-phosphocholine Identifier CHEBI:76076 Charge 0 Formula C26H54NO7P InChIKeyhelp_outline IQGPMZRCLCCXAG-RUZDIDTESA-N SMILEShelp_outline CCCCCCCCCCCCCCCCCC(=O)O[C@H](CO)COP([O-])(=O)OCC[N+](C)(C)C 2D coordinates Mol file for the small molecule Search links Involved in 4 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline H+ Identifier CHEBI:15378 Charge 1 Formula H InChIKeyhelp_outline GPRLSGONYQIRFK-UHFFFAOYSA-N SMILEShelp_outline [H+] 2D coordinates Mol file for the small molecule Search links Involved in 9,176 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine Identifier CHEBI:78097 Charge -1 Formula C57H107NO9P InChIKeyhelp_outline RSIZIZJZWMQYBR-MCBYAYSZSA-M SMILEShelp_outline CCCCCCCCCCCCCCCC(=O)NCCOP([O-])(=O)OC[C@@H](COC(=O)CCCCCCC\C=C/CCCCCCCC)OC(=O)CCCCCCC\C=C/CCCCCCCC 2D coordinates Mol file for the small molecule Search links Involved in 6 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
Cross-references
| RHEA:55252 | RHEA:55253 | RHEA:55254 | RHEA:55255 | |
|---|---|---|---|---|
| Reaction direction help_outline | undefined | left-to-right | right-to-left | bidirectional |
| UniProtKB help_outline |
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Publications
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A calcium-dependent acyltransferase that produces N-acyl phosphatidylethanolamines.
Ogura Y., Parsons W.H., Kamat S.S., Cravatt B.F.
More than 30 years ago, a calcium-dependent enzyme activity was described that generates N-acyl phosphatidylethanolamines (NAPEs), which are precursors for N-acyl ethanolamine (NAE) lipid transmitters, including the endocannabinoid anandamide. The identity of this calcium-dependent N-acyltransfera ... >> More
More than 30 years ago, a calcium-dependent enzyme activity was described that generates N-acyl phosphatidylethanolamines (NAPEs), which are precursors for N-acyl ethanolamine (NAE) lipid transmitters, including the endocannabinoid anandamide. The identity of this calcium-dependent N-acyltransferase (Ca-NAT) has remained mysterious. Here, we use activity-based protein profiling to identify the poorly characterized serine hydrolase PLA2G4E as a mouse brain Ca-NAT and show that this enzyme generates NAPEs and NAEs in mammalian cells. << Less
Nat. Chem. Biol. 12:669-671(2016) [PubMed] [EuropePMC]
This publication is cited by 4 other entries.