Reaction participants Show >> << Hide
- Name help_outline Cu2+ Identifier CHEBI:29036 (CAS: 15158-11-9) help_outline Charge 2 Formula Cu InChIKeyhelp_outline JPVYNHNXODAKFH-UHFFFAOYSA-N SMILEShelp_outline [Cu++] 2D coordinates Mol file for the small molecule Search links Involved in 18 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline L-ascorbate Identifier CHEBI:38290 (Beilstein: 3549814; CAS: 299-36-5) help_outline Charge -1 Formula C6H7O6 InChIKeyhelp_outline CIWBSHSKHKDKBQ-JLAZNSOCSA-M SMILEShelp_outline [H][C@@]1(OC(=O)C(O)=C1[O-])[C@@H](O)CO 2D coordinates Mol file for the small molecule Search links Involved in 34 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline Cu+ Identifier CHEBI:49552 (CAS: 17493-86-6) help_outline Charge 1 Formula Cu InChIKeyhelp_outline VMQMZMRVKUZKQL-UHFFFAOYSA-N SMILEShelp_outline [Cu+] 2D coordinates Mol file for the small molecule Search links Involved in 17 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline H+ Identifier CHEBI:15378 Charge 1 Formula H InChIKeyhelp_outline GPRLSGONYQIRFK-UHFFFAOYSA-N SMILEShelp_outline [H+] 2D coordinates Mol file for the small molecule Search links Involved in 9,176 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline monodehydro-L-ascorbate radical Identifier CHEBI:59513 Charge -1 Formula C6H6O6 InChIKeyhelp_outline LHFJOBMTAJJOTB-JLAZNSOCSA-M SMILEShelp_outline [H][C@@]1(OC(=O)C([O-])=C1[O])[C@@H](O)CO 2D coordinates Mol file for the small molecule Search links Involved in 16 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
Cross-references
| RHEA:66656 | RHEA:66657 | RHEA:66658 | RHEA:66659 | |
|---|---|---|---|---|
| Reaction direction help_outline | undefined | left-to-right | right-to-left | bidirectional |
| UniProtKB help_outline |
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Publications
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Dcytb (Cybrd1) functions as both a ferric and a cupric reductase in vitro.
Wyman S., Simpson R.J., McKie A.T., Sharp P.A.
MDCK cells expressing an inducible duodenal cytochrome b-green fluorescent protein (Dcytb-EGFP) fusion construct were used to investigate the function of Dcytb. The Dcytb-EGFP protein was targeted correctly to the plasma membrane, and cells displayed increased ferric and cupric reductase activitie ... >> More
MDCK cells expressing an inducible duodenal cytochrome b-green fluorescent protein (Dcytb-EGFP) fusion construct were used to investigate the function of Dcytb. The Dcytb-EGFP protein was targeted correctly to the plasma membrane, and cells displayed increased ferric and cupric reductase activities, which were greatly reduced in the presence of doxycycline. The data suggests that Dcytb plays a physiological role in both iron and copper uptake, through divalent metal transporter 1 (DMT1) and copper transporter 1, respectively. In support of this hypothesis, we show that 59Fe uptake was significantly enhanced in Dcytb-EGFP expressing MDCK cells which endogenously express DMT1. << Less
FEBS Lett. 582:1901-1906(2008) [PubMed] [EuropePMC]
This publication is cited by 1 other entry.