Rhea is an expert curated resource of biochemical reactions designed for the annotation of enzymes and genome-scale metabolic networks and models. Rhea uses the ChEBI (Chemical Entities of Biological Interest) ontology of small molecules to precisely describe reactions participants and their chemical structures. All reactions are balanced for mass and charge and are linked to source literature, metabolic resources and other functional vocabularies such as the enzyme classification of the NC-IUBMB.

All data in Rhea is freely accessible and available for anyone to use.

Last release: 85.

News
2017-08-30
Rhea release 85

A new release of Rhea, the annotated database of biochemical reactions, is available.
See Changes.

Check also the most recent publication of Rhea:
Updates in Rhea - a manually curated resource of biochemical reactions
available at PubMed or Nucleic Acid Research

Partners
Rhea is a collaborative effort between the Swiss-Prot Group at the SIB Swiss Institute of Bioinformatics and the EMBL-EBI.
Acknowledgements
Rhea makes use of ChemAxon's Marvin tools.