Enzymes
| UniProtKB help_outline | 1,229 proteins |
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Reaction participants Show >> << Hide
- Name help_outline 2-dehydro-3-deoxy-D-glucarate Identifier CHEBI:58098 Charge -2 Formula C6H6O7 InChIKeyhelp_outline QUURPCHWPQNNGL-OKKQSCSOSA-L SMILEShelp_outline O[C@@H](CC(=O)C([O-])=O)[C@H](O)C([O-])=O 2D coordinates Mol file for the small molecule Search links Involved in 1 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline 2-hydroxy-3-oxopropanoate Identifier CHEBI:57978 Charge -1 Formula C3H3O4 InChIKeyhelp_outline QWBAFPFNGRFSFB-UHFFFAOYSA-M SMILEShelp_outline [H]C(=O)C(O)C([O-])=O 2D coordinates Mol file for the small molecule Search links Involved in 7 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline pyruvate Identifier CHEBI:15361 (Beilstein: 3587721; CAS: 57-60-3) help_outline Charge -1 Formula C3H3O3 InChIKeyhelp_outline LCTONWCANYUPML-UHFFFAOYSA-M SMILEShelp_outline CC(=O)C([O-])=O 2D coordinates Mol file for the small molecule Search links Involved in 201 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
Cross-references
| RHEA:10268 | RHEA:10269 | RHEA:10270 | RHEA:10271 | |
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| Reaction direction help_outline | undefined | left-to-right | right-to-left | bidirectional |
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Publications
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Evolution of enzymatic activities in the enolase superfamily: characterization of the (D)-glucarate/galactarate catabolic pathway in Escherichia coli.
Hubbard B.K., Koch M., Palmer D.R., Babbitt P.C., Gerlt J.A.
The genes encoding the enzymes in the (D)-glucarate/galactarate catabolic pathway have been identified in the Escherichia coli genome. These encode, in three transcriptional units, (D)-glucarate dehydratase (GlucD), galactarate dehydratase, 5-keto-4-deoxy-(D)-glucarate aldolase, tartronate semiald ... >> More
The genes encoding the enzymes in the (D)-glucarate/galactarate catabolic pathway have been identified in the Escherichia coli genome. These encode, in three transcriptional units, (D)-glucarate dehydratase (GlucD), galactarate dehydratase, 5-keto-4-deoxy-(D)-glucarate aldolase, tartronate semialdehyde reductase, a glycerate kinase that generates 2-phosphoglycerate as product, and two hexaric acid transporters. We also have identified a gene proximal to that encoding GlucD that encodes a protein that is 72% identical in primary sequence to GlucD (GlucD-related protein or GlucDRP). However, whereas GlucD catalyzes the efficient dehydration of both (D)-glucarate and (L)-idarate as well as their epimerization, GlucDRP is significantly impaired in both reactions. Perhaps GlucDRP is an example of gene duplication and evolution in progress in the E. coli chromosome. << Less
Biochemistry 37:14369-14375(1998) [PubMed] [EuropePMC]
This publication is cited by 5 other entries.