RHEA:10268
| Enzymes help_outline | 1,174 proteins (UniProtKB) |
| Enzyme class help_outline |
Reaction participants Show >> << Hide
- Name help_outline 2-dehydro-3-deoxy-D-glucarate Identifier CHEBI:58098 Charge -2 Formula C6H6O7 InChIKeyhelp_outline QUURPCHWPQNNGL-OKKQSCSOSA-L SMILEShelp_outline O[C@@H](CC(=O)C([O-])=O)[C@H](O)C([O-])=O 2D coordinates Mol file for the small molecule Search links Involved in 1 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline 2-hydroxy-3-oxopropanoate Identifier CHEBI:57978 Charge -1 Formula C3H3O4 InChIKeyhelp_outline QWBAFPFNGRFSFB-UHFFFAOYSA-M SMILEShelp_outline [H]C(=O)C(O)C([O-])=O 2D coordinates Mol file for the small molecule Search links Involved in 7 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline pyruvate Identifier CHEBI:15361 (Beilstein: 3587721; CAS: 57-60-3) help_outline Charge -1 Formula C3H3O3 InChIKeyhelp_outline LCTONWCANYUPML-UHFFFAOYSA-M SMILEShelp_outline CC(=O)C([O-])=O 2D coordinates Mol file for the small molecule Search links Involved in 200 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
Links to other resources
| RHEA:10268 | RHEA:10269 | RHEA:10270 | RHEA:10271 | |
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| Reaction direction help_outline | undefined | left-to-right | right-to-left | bidirectional |
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Citations
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Evolution of enzymatic activities in the enolase superfamily: characterization of the (D)-glucarate/galactarate catabolic pathway in Escherichia coli.
Hubbard B.K., Koch M., Palmer D.R., Babbitt P.C., Gerlt J.A.
The genes encoding the enzymes in the (D)-glucarate/galactarate catabolic pathway have been identified in the Escherichia coli genome. These encode, in three transcriptional units, (D)-glucarate dehydratase (GlucD), galactarate dehydratase, 5-keto-4-deoxy-(D)-glucarate aldolase, tartronate semiald ... >> More
The genes encoding the enzymes in the (D)-glucarate/galactarate catabolic pathway have been identified in the Escherichia coli genome. These encode, in three transcriptional units, (D)-glucarate dehydratase (GlucD), galactarate dehydratase, 5-keto-4-deoxy-(D)-glucarate aldolase, tartronate semialdehyde reductase, a glycerate kinase that generates 2-phosphoglycerate as product, and two hexaric acid transporters. We also have identified a gene proximal to that encoding GlucD that encodes a protein that is 72% identical in primary sequence to GlucD (GlucD-related protein or GlucDRP). However, whereas GlucD catalyzes the efficient dehydration of both (D)-glucarate and (L)-idarate as well as their epimerization, GlucDRP is significantly impaired in both reactions. Perhaps GlucDRP is an example of gene duplication and evolution in progress in the E. coli chromosome. << Less
Biochemistry 37:14369-14375(1998) [PubMed] [EuropePMC]
This publication is cited by 5 other entries.