Current release 120 (2021-11-17): 13,909 reactions with 12,081 unique compounds from 15,710 unique references (see statistics and news)

Find Rhea reactions

Rhea is an expert-curated knowledgebase of chemical and transport reactions of biological interest - and the standard for enzyme and transporter annotation in UniProtKB. Rhea uses the chemical dictionary ChEBI (Chemical Entities of Biological Interest) to describe reaction participants. Learn more... Cite us: Rhea, the reaction knowledgebase in 2022 PMID:34755880 DOI:

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Key features & web interface

Web interface & reaction pages

Tutorials: How to search Rhea by


Chemical classes (ChEBI)

Chemical structures (InChIKey)


Gene Ontology


Enzyme classes (EC)

Enzymes (UniProt)

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