Current release 139 (2025-06-18): 17,783 reactions with 14,654 unique compounds from 18,435 unique references (see statistics and news)

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Rhea is an expert-curated knowledgebase of chemical and transport reactions of biological interest - and the standard for enzyme and transporter annotation in UniProtKB. Rhea uses the chemical dictionary ChEBI (Chemical Entities of Biological Interest) to describe reaction participants. Learn more... Cite us: Rhea, the reaction knowledgebase in 2022 (PMID:34755880, DOI:10.1093/nar/gkab1016)

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chebi

Chemical classes (ChEBI)

Chemical structures (InChIKey)

chemistry

Substructures and similarity

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Gene Ontology

EC

Enzyme classes (EC)

Enzymes (UniProt)

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