Enzymes
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- Name help_outline 1-(4-amino-2-methylpyrimid-5-ylmethyl)-3-(2-hydroxyethyl)-2-methylpyridinium Identifier CHEBI:72290 Charge 1 Formula C14H19N4O InChIKeyhelp_outline PZWYDZMWPANLMB-UHFFFAOYSA-N SMILEShelp_outline Cc1ncc(C[n+]2cccc(CCO)c2C)c(N)n1 2D coordinates Mol file for the small molecule Search links Involved in 1 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline H+ Identifier CHEBI:15378 Charge 1 Formula H InChIKeyhelp_outline GPRLSGONYQIRFK-UHFFFAOYSA-N SMILEShelp_outline [H+] 2D coordinates Mol file for the small molecule Search links Involved in 9,176 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline H2O Identifier CHEBI:15377 (Beilstein: 3587155; CAS: 7732-18-5) help_outline Charge 0 Formula H2O InChIKeyhelp_outline XLYOFNOQVPJJNP-UHFFFAOYSA-N SMILEShelp_outline [H]O[H] 2D coordinates Mol file for the small molecule Search links Involved in 6,048 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline 1-(4-hydroxy-2-methylpyrimid-5-ylmethyl)-3-(2-hydroxyethyl)-2-methylpyridinium Identifier CHEBI:57975 Charge 1 Formula C14H18N3O2 InChIKeyhelp_outline PINBHFPAOLBYDE-UHFFFAOYSA-O SMILEShelp_outline Cc1ncc(C[n+]2cccc(CCO)c2C)c(O)n1 2D coordinates Mol file for the small molecule Search links Involved in 1 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline NH4+ Identifier CHEBI:28938 (CAS: 14798-03-9) help_outline Charge 1 Formula H4N InChIKeyhelp_outline QGZKDVFQNNGYKY-UHFFFAOYSA-O SMILEShelp_outline [H][N+]([H])([H])[H] 2D coordinates Mol file for the small molecule Search links Involved in 518 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
Cross-references
| RHEA:14537 | RHEA:14538 | RHEA:14539 | RHEA:14540 | |
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| Reaction direction help_outline | undefined | left-to-right | right-to-left | bidirectional |
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Publications
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Metabolism of pyrithiamine by the pyrithiamine-requiring mutant of Staphylococcus aureus.
Sinha A.K., Chatterjee G.C.
1. A mutant strain of Staphylococcus aureus that requires pyrithiamine for its optimum growth was found to utilize pyrithiamine during the exponential phase of growth. 2. Pyrithiamine was deaminated by the organism to form oxypyrithiamine, the reaction being enzymic with no cofactor requirement. 3 ... >> More
1. A mutant strain of Staphylococcus aureus that requires pyrithiamine for its optimum growth was found to utilize pyrithiamine during the exponential phase of growth. 2. Pyrithiamine was deaminated by the organism to form oxypyrithiamine, the reaction being enzymic with no cofactor requirement. 3. On prolonged incubation of S. aureus A cultures, the concentration of deaminating enzyme increased in the culture broth, from which pyrithiamine-deaminating enzyme could be isolated by solvent fractionation. 4. Oxypyrithiamine is not a competitive analogue of thiamine although it inhibited the growth of the parent strain of S. aureus; the inhibition index of this compound, however, was lower than that of pyrithiamine. << Less