Rhea - reaction knowledgebase

Enzymes

UniProtKB ^help_outline	1 proteins
Enzyme class ^help_outline	EC 3.1.1.68 xylono-1,4-lactonase
GO Molecular Function ^help_outline	GO:0050402 xylono-1,4-lactonase activity

Reaction participants Show >> << Hide

Name ^help_outline D-xylono-1,4-lactone Identifier CHEBI:16392 (Beilstein: 82061; CAS: 15384-37-9) ^help_outline Charge 0 Formula C5H8O5 InChIKey^help_outline CUOKHACJLGPRHD-FLRLBIABSA-N SMILES^help_outline [C@@H]1(OC([C@@H]([C@H]1O)O)=O)CO 2D coordinates Mol file for the small molecule Search links Involved in 2 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
Name ^help_outline H₂O Identifier CHEBI:15377 (Beilstein: 3587155; CAS: 7732-18-5) ^help_outline Charge 0 Formula H2O InChIKey^help_outline XLYOFNOQVPJJNP-UHFFFAOYSA-N SMILES^help_outline [H]O[H] 2D coordinates Mol file for the small molecule Search links Involved in 6,048 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
Name ^help_outline D-xylonate Identifier CHEBI:17746 Charge -1 Formula C5H9O6 InChIKey^help_outline QXKAIJAYHKCRRA-FLRLBIABSA-M SMILES^help_outline OC[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O 2D coordinates Mol file for the small molecule Search links Involved in 3 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
Name ^help_outline H⁺ Identifier CHEBI:15378 Charge 1 Formula H InChIKey^help_outline GPRLSGONYQIRFK-UHFFFAOYSA-N SMILES^help_outline [H+] 2D coordinates Mol file for the small molecule Search links Involved in 9,176 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule

Cross-references

	RHEA:18341	RHEA:18342	RHEA:18343	RHEA:18344
Reaction direction	undefined	left-to-right	right-to-left	bidirectional
UniProtKB ^help_outline	1 proteins
EC numbers ^help_outline	3.1.1.68
Gene Ontology ^help_outline	GO:0050402
KEGG ^help_outline				R02428
MetaCyc ^help_outline		RXN-19753

Publications

Characterization of a pentonolactonase involved in D-xylose and L-arabinose catabolism in the haloarchaeon Haloferax volcanii.

Sutter J.M., Johnsen U., Schoenheit P.

Haloferax volcanii degrades the pentoses D-xylose and L-arabinose via an oxidative pathway to α-ketoglutarate as an intermediate. The initial dehydrogenases of the pathway, D-xylose dehydrogenase (XDH) and L-arabinose dehydrogenase (L-AraDH) catalyze the NADP+ dependent D-xylose and L-arabinose ox ... >> More

Haloferax volcanii degrades the pentoses D-xylose and L-arabinose via an oxidative pathway to α-ketoglutarate as an intermediate. The initial dehydrogenases of the pathway, D-xylose dehydrogenase (XDH) and L-arabinose dehydrogenase (L-AraDH) catalyze the NADP+ dependent D-xylose and L-arabinose oxidation. It is shown here that the pentoses are oxidized to the corresponding lactones, D-xylono-γ-lactone and L-arabino-γ-lactone, rather than to the respective sugar acids. A putative lactonase gene, xacC, located in genomic vicinity of XDH and L-AraDH, was found to be transcriptionally upregulated by both D-xylose and L-arabinose mediated by the pentose-specific regulator XacR. The recombinant lactonase catalyzed the hydrolysis of D-xylono-γ-lactone and L-arabino-γ-lactone. This is the first report of a functional lactonase involved in sugar catabolism in the domain of archaea. << Less

FEMS Microbiol. Lett. 364:0-0(2017) [PubMed] [EuropePMC]

This publication is cited by 1 other entry.

Comments

Published in: Buchert, J. and Viikari, L. The role of xylonolactone in xylonic acid production by Pseudomonas fragi. Appl. Microbiol. Biotechnol. 27 (1988) 333–336. This reaction can occur spontaneously.