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- Name help_outline 3-chloro-D-alanine Identifier CHEBI:47291 Charge 0 Formula C3H6ClNO2 InChIKeyhelp_outline ASBJGPTTYPEMLP-UWTATZPHSA-N SMILEShelp_outline [NH3+][C@H](CCl)C([O-])=O 2D coordinates Mol file for the small molecule Search links Involved in 2 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline H2O Identifier CHEBI:15377 (Beilstein: 3587155; CAS: 7732-18-5) help_outline Charge 0 Formula H2O InChIKeyhelp_outline XLYOFNOQVPJJNP-UHFFFAOYSA-N SMILEShelp_outline [H]O[H] 2D coordinates Mol file for the small molecule Search links Involved in 6,048 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline chloride Identifier CHEBI:17996 (Beilstein: 3587171; CAS: 16887-00-6) help_outline Charge -1 Formula Cl InChIKeyhelp_outline VEXZGXHMUGYJMC-UHFFFAOYSA-M SMILEShelp_outline [Cl-] 2D coordinates Mol file for the small molecule Search links Involved in 139 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline H+ Identifier CHEBI:15378 Charge 1 Formula H InChIKeyhelp_outline GPRLSGONYQIRFK-UHFFFAOYSA-N SMILEShelp_outline [H+] 2D coordinates Mol file for the small molecule Search links Involved in 9,176 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline NH4+ Identifier CHEBI:28938 (CAS: 14798-03-9) help_outline Charge 1 Formula H4N InChIKeyhelp_outline QGZKDVFQNNGYKY-UHFFFAOYSA-O SMILEShelp_outline [H][N+]([H])([H])[H] 2D coordinates Mol file for the small molecule Search links Involved in 518 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline pyruvate Identifier CHEBI:15361 (Beilstein: 3587721; CAS: 57-60-3) help_outline Charge -1 Formula C3H3O3 InChIKeyhelp_outline LCTONWCANYUPML-UHFFFAOYSA-M SMILEShelp_outline CC(=O)C([O-])=O 2D coordinates Mol file for the small molecule Search links Involved in 213 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
Cross-references
| RHEA:18873 | RHEA:18874 | RHEA:18875 | RHEA:18876 | |
|---|---|---|---|---|
| Reaction direction help_outline | undefined | left-to-right | right-to-left | bidirectional |
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Publications
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Physiological comparison of D-cysteine desulfhydrase of Escherichia coli with 3-chloro-D-alanine dehydrochlorinase of Pseudomonas putida CR 1-1.
Nagasawa T., Ishii T., Yamada H.
D-Cysteine desulfhydrase of Escherichia coli W3110 delta trpED102/F' delta trpED102 was physiologically characterized. It was found to be located in the cytosolic fraction, as 3-chloro-D-alanine dehydrochlorinase is. D-Cysteine desulfhydrase catalyzed not only the alpha, beta-elimination reaction ... >> More
D-Cysteine desulfhydrase of Escherichia coli W3110 delta trpED102/F' delta trpED102 was physiologically characterized. It was found to be located in the cytosolic fraction, as 3-chloro-D-alanine dehydrochlorinase is. D-Cysteine desulfhydrase catalyzed not only the alpha, beta-elimination reaction of O-acetyl-D-serine to form pyruvate, acetic acid and ammonia, but also the beta-replacement reaction of O-acetyl-D-serine with sulfide to form D-cysteine. However, these reactions appeared not to proceed in vivo. No other activity of D-cysteine synthesis from O-acetyl-D-serine and sulfide was detected in a crude cell extract of E. coli which was immunotitrated with antibodies raised against the purified D-cysteine desulfhydrase. Although D-cysteine desulfhydrase catalyzes the degradation (alpha, beta-elimination reaction) of 3-chloro-D-alanine, which is an effective antibacterial agent, E. coli W3110 delta trpED102/F' delta trpED102 did not show resistance against 3-chloro-D-alanine. Therefore, D-cysteine desulfhydrase does not contribute to 3-chloro-D-alanine detoxification in vivo. << Less
Arch Microbiol 149:413-416(1988) [PubMed] [EuropePMC]
This publication is cited by 1 other entry.
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Synthesis of D-cysteine from 3-chloro-D-alanine and hydrogen sulfide by 3-chloro-D-alanine hydrogen chloride-lyase (deaminating) of Pseudomonas putida.
Yamada H., Nagasawa T., Ohkishi H., Kawakami B., Tani Y.
Biochem Biophys Res Commun 100:1104-1110(1981) [PubMed] [EuropePMC]
This publication is cited by 1 other entry.
Comments
Multi-step reaction: RHEA:43032 + RHEA:40667 + RHEA:40671