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RHEA:19953 a 2-oxocarboxylate + L-alanine = an L-alpha-amino acid + pyruvate

Enzymes

Enzyme class ^help_outline	EC 2.6.1.12 alanine--oxo-acid transaminase
GO Molecular Function ^help_outline	GO:0047635 alanine-oxo-acid transaminase activity

Reaction participants Show >> << Hide

Name ^help_outline a 2-oxocarboxylate Identifier CHEBI:35179 Charge -1 Formula C2O3R SMILES^help_outline [O-]C(=O)C([*])=O 2D coordinates Mol file for the small molecule Search links Involved in 586 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
Name ^help_outline L-alanine Identifier CHEBI:57972 Charge 0 Formula C3H7NO2 InChIKey^help_outline QNAYBMKLOCPYGJ-REOHCLBHSA-N SMILES^help_outline C[C@H]([NH3+])C([O-])=O 2D coordinates Mol file for the small molecule Search links Involved in 107 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
Name ^help_outline an L-α-amino acid Identifier CHEBI:59869 Charge 0 Formula C2H4NO2R SMILES^help_outline [NH3+][C@@H]([*])C([O-])=O 2D coordinates Mol file for the small molecule Search links Involved in 355 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
Name ^help_outline pyruvate Identifier CHEBI:15361 (Beilstein: 3587721; CAS: 57-60-3) ^help_outline Charge -1 Formula C3H3O3 InChIKey^help_outline LCTONWCANYUPML-UHFFFAOYSA-M SMILES^help_outline CC(=O)C([O-])=O 2D coordinates Mol file for the small molecule Search links Involved in 213 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule

Cross-references

	RHEA:19953	RHEA:19954	RHEA:19955	RHEA:19956
Reaction direction	undefined	left-to-right	right-to-left	bidirectional
UniProtKB ^help_outline
EC numbers ^help_outline	2.6.1.12
Gene Ontology ^help_outline	GO:0047635
KEGG ^help_outline				R01261
MetaCyc ^help_outline				ALANINE--OXO-ACID-AMINOTRANSFERASE-RXN

Related reactions ^help_outline

Specific form(s) of this reaction

RHEA:77355
2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate
RHEA:77347
L-alanine + oxaloacetate = L-aspartate + pyruvate
RHEA:77327
L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
RHEA:77319
N^ω-methyl-L-arginine + pyruvate = 5-(3-methylguanidino)-2-oxopentanoate + L-alanine
RHEA:77307
N^ω,N^'ω-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
RHEA:77303
N^ω,N^ω-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine
RHEA:68372
L-asparagine + pyruvate = 2-oxosuccinamate + L-alanine
RHEA:65920
L-kynurenine + pyruvate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-alanine
RHEA:27586
L-tryptophan + pyruvate = indole-3-pyruvate + L-alanine
RHEA:24248
glyoxylate + L-alanine = glycine + pyruvate
RHEA:22912
L-valine + pyruvate = 3-methyl-2-oxobutanoate + L-alanine
RHEA:22852
L-serine + pyruvate = 3-hydroxypyruvate + L-alanine
RHEA:19453
2-oxoglutarate + L-alanine = L-glutamate + pyruvate
RHEA:13833
L-arginine + pyruvate = 5-guanidino-2-oxopentanoate + L-alanine
RHEA:13053
L-phenylalanine + pyruvate = 3-phenylpyruvate + L-alanine
RHEA:10400
L-glutamine + pyruvate = 2-oxoglutaramate + L-alanine

Publications

Transamination reactions in plants.

WILSON D.G., KING K.W., BURRIS R.H.

J Biol Chem 208:863-874(1954) [PubMed] [EuropePMC]
Transaminations with pyruvate and other alpha-keto acids.

ROWSELL E.V.

Biochem J 64:246-252(1956) [PubMed] [EuropePMC]
Transaminases in smooth Brucella abortus, strain 19.

ALTENBERN R.A., HOUSEWRIGHT R.D.

J Biol Chem 204:159-167(1953) [PubMed] [EuropePMC]
Formation of serine hydroxypryuvate and L-alanine.

SALLACH H.J.

J Biol Chem 223:1101-1108(1956) [PubMed] [EuropePMC]