Enzymes
UniProtKB help_outline | 2 proteins |
Enzyme class help_outline |
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Reaction participants Show >> << Hide
- Name help_outline D-glutamate Identifier CHEBI:29986 (Beilstein: 8319427) help_outline Charge -1 Formula C5H8NO4 InChIKeyhelp_outline WHUUTDBJXJRKMK-GSVOUGTGSA-M SMILEShelp_outline [NH3+][C@H](CCC([O-])=O)C([O-])=O 2D coordinates Mol file for the small molecule Search links Involved in 13 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline 5-oxo-D-proline Identifier CHEBI:57948 Charge -1 Formula C5H6NO3 InChIKeyhelp_outline ODHCTXKNWHHXJC-GSVOUGTGSA-M SMILEShelp_outline [O-]C(=O)[C@H]1CCC(=O)N1 2D coordinates Mol file for the small molecule Search links Involved in 1 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline H2O Identifier CHEBI:15377 (Beilstein: 3587155; CAS: 7732-18-5) help_outline Charge 0 Formula H2O InChIKeyhelp_outline XLYOFNOQVPJJNP-UHFFFAOYSA-N SMILEShelp_outline [H]O[H] 2D coordinates Mol file for the small molecule Search links Involved in 6,048 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
Cross-references
RHEA:22360 | RHEA:22361 | RHEA:22362 | RHEA:22363 | |
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Reaction direction help_outline | undefined | left-to-right | right-to-left | bidirectional |
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Publications
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D-Glutamate is metabolized in the heart mitochondria.
Ariyoshi M., Katane M., Hamase K., Miyoshi Y., Nakane M., Hoshino A., Okawa Y., Mita Y., Kaimoto S., Uchihashi M., Fukai K., Ono K., Tateishi S., Hato D., Yamanaka R., Honda S., Fushimura Y., Iwai-Kanai E., Ishihara N., Mita M., Homma H., Matoba S.
<sub>D</sub>-Amino acids are enantiomers of L-amino acids and have recently been recognized as biomarkers and bioactive substances in mammals, including humans. In the present study, we investigated functions of the novel mammalian mitochondrial protein 9030617O03Rik and showed decreased expressio ... >> More
<sub>D</sub>-Amino acids are enantiomers of L-amino acids and have recently been recognized as biomarkers and bioactive substances in mammals, including humans. In the present study, we investigated functions of the novel mammalian mitochondrial protein 9030617O03Rik and showed decreased expression under conditions of heart failure. Genomic sequence analyses showed partial homology with a bacterial aspartate/glutamate/hydantoin racemase. Subsequent determinations of all free amino acid concentrations in 9030617O03Rik-deficient mice showed high accumulations of D-glutamate in heart tissues. This is the first time that a significant amount of D-glutamate was detected in mammalian tissue. Further analysis of D-glutamate metabolism indicated that 9030617O03Rik is a D-glutamate cyclase that converts D-glutamate to 5-oxo-D-proline. Hence, this protein is the first identified enzyme responsible for mammalian D-glutamate metabolism, as confirmed in cloning analyses. These findings suggest that D-glutamate and 5-oxo-D-proline have bioactivities in mammals through the metabolism by D-glutamate cyclase. << Less
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THE OPTICALLY-SPECIFIC ENZYMATIC CYCLIZATION OF D-GLUTAMATE.
MEISTER A., BUKENBERGER M.W., STRASSBURGER M.