Reaction participants Show >> << Hide
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Namehelp_outline
holo-[cytochrome c]
Identifier
RHEA-COMP:10726
Reactive part
help_outline
- Name help_outline holocytochrome c residue Identifier CHEBI:83739 Charge -2 Formula C40H40FeN6O6S2 SMILEShelp_outline CC(SC[C@H](N-*)C(-*)=O)C1=C(C)C2=[N+]3C1=Cc1c(C)c(CCC([O-])=O)c4C=C5C(CCC([O-])=O)=C(C)C6=[N+]5[Fe--]3(n14)n1c(=C6)c(C)c(C(C)SC[C@H](N-*)C(-*)=O)c1=C2 2D coordinates Mol file for the small molecule Search links Involved in 1 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
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Namehelp_outline
apo-[cytochrome c]
Identifier
RHEA-COMP:10725
Reactive part
help_outline
- Name help_outline L-cysteine residue Identifier CHEBI:29950 Charge 0 Formula C3H5NOS Positionhelp_outline n SMILEShelp_outline C(=O)(*)[C@@H](N*)CS 2D coordinates Mol file for the small molecule Search links Involved in 123 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline L-cysteine residue Identifier CHEBI:29950 Charge 0 Formula C3H5NOS Positionhelp_outline n+3 SMILEShelp_outline C(=O)(*)[C@@H](N*)CS 2D coordinates Mol file for the small molecule Search links Involved in 123 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline heme b Identifier CHEBI:60344 Charge -2 Formula C34H30FeN4O4 InChIKeyhelp_outline KABFMIBPWCXCRK-RGGAHWMASA-J SMILEShelp_outline CC1=C(CCC([O-])=O)C2=[N+]3C1=Cc1c(C)c(C=C)c4C=C5C(C)=C(C=C)C6=[N+]5[Fe--]3(n14)n1c(=C6)c(C)c(CCC([O-])=O)c1=C2 2D coordinates Mol file for the small molecule Search links Involved in 22 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
Cross-references
| RHEA:22648 | RHEA:22649 | RHEA:22650 | RHEA:22651 | |
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| Reaction direction help_outline | undefined | left-to-right | right-to-left | bidirectional |
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Publications
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Identification and sequence of the gene encoding cytochrome c heme lyase in the yeast Saccharomyces cerevisiae.
Dumont M.E., Ernst J.F., Hampsey D.M., Sherman F.
Mitochondrial cytochrome c contains a heme group covalently attached through thioether linkages to two cysteinyl residues of the protein. We demonstrate here that the nuclear gene, CYC3, in the yeast Saccharomyces cerevisiae, encodes cytochrome c heme lyase (CCHL), the enzyme catalyzing the attach ... >> More
Mitochondrial cytochrome c contains a heme group covalently attached through thioether linkages to two cysteinyl residues of the protein. We demonstrate here that the nuclear gene, CYC3, in the yeast Saccharomyces cerevisiae, encodes cytochrome c heme lyase (CCHL), the enzyme catalyzing the attachment of heme to apocytochrome c. Mitochondrial extracts from cyc3-mutants are deficient in CCHL activity compared with extracts from normal strains, whereas strains carrying multiple copies of the CYC3 gene exhibit high levels of the activity. The CYC3 gene was cloned by functional complementation of a cyc3-mutant using a previously isolated plasmid containing the gene PYK1, which is tightly linked to CYC3. An open reading frame encoding a protein of 269 amino acids was identified from the DNA sequence of a fragment encompassing the CYC3 gene, and the corresponding transcript shown to be approximately 0.9 kb in length. CCHL appears to be a single polypeptide chain which acts specifically on the two forms of cytochrome c, but not on cytochrome c1. << Less