Rhea - reaction knowledgebase

Enzymes

UniProtKB ^help_outline	2 proteins
Enzyme class ^help_outline	EC 1.1.1.274 2,5-didehydrogluconate reductase (2-dehydro-D-gluconate-forming)
GO Molecular Function ^help_outline	GO:0050580 2,5-didehydrogluconate reductase activity

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Name ^help_outline 2-dehydro-D-gluconate Identifier CHEBI:16808 (Beilstein: 3907127) ^help_outline Charge -1 Formula C6H9O7 InChIKey^help_outline VBUYCZFBVCCYFD-JJYYJPOSSA-M SMILES^help_outline OC[C@@H](O)[C@@H](O)[C@H](O)C(=O)C([O-])=O 2D coordinates Mol file for the small molecule Search links Involved in 6 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
Name ^help_outline NADP⁺ Identifier CHEBI:58349 Charge -3 Formula C21H25N7O17P3 InChIKey^help_outline XJLXINKUBYWONI-NNYOXOHSSA-K SMILES^help_outline NC(=O)c1ccc[n+](c1)[C@@H]1O[C@H](COP([O-])(=O)OP([O-])(=O)OC[C@H]2O[C@H]([C@H](OP([O-])([O-])=O)[C@@H]2O)n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O 2D coordinates Mol file for the small molecule Search links Involved in 1,253 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
Name ^help_outline 2,5-didehydro-D-gluconate Identifier CHEBI:11449 (Beilstein: 3671140) ^help_outline Charge -1 Formula C6H7O7 InChIKey^help_outline RXMWXENJQAINCC-DMTCNVIQSA-M SMILES^help_outline OCC(=O)[C@@H](O)[C@H](O)C(=O)C([O-])=O 2D coordinates Mol file for the small molecule Search links Involved in 5 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
Name ^help_outline H⁺ Identifier CHEBI:15378 Charge 1 Formula H InChIKey^help_outline GPRLSGONYQIRFK-UHFFFAOYSA-N SMILES^help_outline [H+] 2D coordinates Mol file for the small molecule Search links Involved in 9,176 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
Name ^help_outline NADPH Identifier CHEBI:57783 (Beilstein: 10411862) ^help_outline Charge -4 Formula C21H26N7O17P3 InChIKey^help_outline ACFIXJIJDZMPPO-NNYOXOHSSA-J SMILES^help_outline NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](COP([O-])(=O)OP([O-])(=O)OC[C@H]2O[C@H]([C@H](OP([O-])([O-])=O)[C@@H]2O)n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O 2D coordinates Mol file for the small molecule Search links Involved in 1,247 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule

Cross-references

	RHEA:23828	RHEA:23829	RHEA:23830	RHEA:23831
Reaction direction	undefined	left-to-right	right-to-left	bidirectional
UniProtKB ^help_outline	2 proteins
EC numbers ^help_outline	1.1.1.274
Gene Ontology ^help_outline	GO:0050580
KEGG ^help_outline				R05823
MetaCyc ^help_outline				1.1.1.274-RXN
EcoCyc ^help_outline			1.1.1.274-RXN

Related reactions ^help_outline

More general form(s) of this reaction

RHEA:12368
2-dehydro-D-gluconate + A = 2,5-didehydro-D-gluconate + AH₂

Comments

Published in: "Biochemical aspects of 2-keto-L-gulonate accumulation from 2,5-diketo-D-gluconate by Corynebacterium sp. and its mutants." Sonoyama, T., Kageyama, B., Yagi, S. and Mitsushima, K. Agric. Biol. Chem. 51 (1987) 3039–3047.