Reaction participants Show >> << Hide
- Name help_outline 5,6-dihydroxyindole Identifier CHEBI:27404 (CAS: 3131-52-0) help_outline Charge 0 Formula C8H7NO2 InChIKeyhelp_outline SGNZYJXNUURYCH-UHFFFAOYSA-N SMILEShelp_outline Oc1cc2cc[nH]c2cc1O 2D coordinates Mol file for the small molecule Search links Involved in 3 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline O2 Identifier CHEBI:15379 (CAS: 7782-44-7) help_outline Charge 0 Formula O2 InChIKeyhelp_outline MYMOFIZGZYHOMD-UHFFFAOYSA-N SMILEShelp_outline O=O 2D coordinates Mol file for the small molecule Search links Involved in 2,851 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline indole-5,6-quinone Identifier CHEBI:27406 Charge 0 Formula C8H5NO2 InChIKeyhelp_outline IGGVVGHJSQSLFO-UHFFFAOYSA-N SMILEShelp_outline O=C1C=c2cc[nH]c2=CC1=O 2D coordinates Mol file for the small molecule Search links Involved in 1 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline H2O Identifier CHEBI:15377 (CAS: 7732-18-5) help_outline Charge 0 Formula H2O InChIKeyhelp_outline XLYOFNOQVPJJNP-UHFFFAOYSA-N SMILEShelp_outline [H]O[H] 2D coordinates Mol file for the small molecule Search links Involved in 6,485 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
Cross-references
| RHEA:33515 | RHEA:33516 | RHEA:33517 | RHEA:33518 | |
|---|---|---|---|---|
| Reaction direction help_outline | undefined | left-to-right | right-to-left | bidirectional |
| UniProtKB help_outline |
|
|||
| KEGG help_outline | ||||
| MetaCyc help_outline |
Publications
-
Generation of hydrogen peroxide in the melanin biosynthesis pathway.
Munoz-Munoz J.L., Garcia-Molina F., Varon R., Tudela J., Garcia-Canovas F., Rodriguez-Lopez J.N.
The generation of H(2)O(2) in the melanin biosynthesis pathway is of great importance because of its great cytotoxic capacity. However, there is controversy concerning the way in which H(2)O(2) is generated in this pathway. In this work we demonstrate that it is generated in a series of chemical r ... >> More
The generation of H(2)O(2) in the melanin biosynthesis pathway is of great importance because of its great cytotoxic capacity. However, there is controversy concerning the way in which H(2)O(2) is generated in this pathway. In this work we demonstrate that it is generated in a series of chemical reactions coupled to the enzymatic formation of o-quinones by tyrosinase acting on monophenols and o-diphenols and during the auto-oxidation of the o-diphenols and other intermediates in the pathway. The use of the enzymes such as catalase, superoxide dismutase and peroxidase helps reveal the H(2)O(2) generated. Based on the results obtained, we propose a scheme of enzymatic and non-enzymatic reactions that lead to the biosynthesis of melanins, which explains the formation of H(2)O(2). << Less
Biochim Biophys Acta 1794:1017-1029(2009) [PubMed] [EuropePMC]