Enzymes
| UniProtKB help_outline | 1 proteins |
Reaction participants Show >> << Hide
- Name help_outline 15-methylhexadecasphing-4-enine 1-phosphate Identifier CHEBI:70991 Charge -1 Formula C17H35NO5P InChIKeyhelp_outline KGHLSJONZZZQPJ-KORIGIIASA-M SMILEShelp_outline CC(C)CCCCCCCCC\C=C\[C@@H](O)[C@@H]([NH3+])COP([O-])([O-])=O 2D coordinates Mol file for the small molecule Search links Involved in 3 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline (2E)-13-methyltetradecenal Identifier CHEBI:70995 Charge 0 Formula C15H28O InChIKeyhelp_outline XCQVBFWYULNOQE-ZRDIBKRKSA-N SMILEShelp_outline [H]C(=O)\C=C\CCCCCCCCCC(C)C 2D coordinates Mol file for the small molecule Search links Involved in 1 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline phosphoethanolamine Identifier CHEBI:58190 Charge -1 Formula C2H7NO4P InChIKeyhelp_outline SUHOOTKUPISOBE-UHFFFAOYSA-M SMILEShelp_outline [NH3+]CCOP([O-])([O-])=O 2D coordinates Mol file for the small molecule Search links Involved in 18 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
Cross-references
| RHEA:34719 | RHEA:34720 | RHEA:34721 | RHEA:34722 | |
|---|---|---|---|---|
| Reaction direction help_outline | undefined | left-to-right | right-to-left | bidirectional |
| UniProtKB help_outline |
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Related reactions help_outline
More general form(s) of this reaction
Publications
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The BST1 gene of Saccharomyces cerevisiae is the sphingosine-1-phosphate lyase.
Saba J.D., Nara F., Bielawska A., Garrett S., Hannun Y.A.
Sphingolipids elicit a wide variety of eukaryotic cellular responses, most involving regulation of cell growth, differentiation, and apoptosis. Sphingosine 1-phosphate, a sphingolipid catabolite, is mitogenic in fibroblasts and inhibits the chemotactic mobility and invasiveness of human tumor cell ... >> More
Sphingolipids elicit a wide variety of eukaryotic cellular responses, most involving regulation of cell growth, differentiation, and apoptosis. Sphingosine 1-phosphate, a sphingolipid catabolite, is mitogenic in fibroblasts and inhibits the chemotactic mobility and invasiveness of human tumor cells. Sphingosine 1-phosphate degradation requires cleavage at the C2-3 carbon bond by sphingosine phosphate lyase. A yeast genetic approach was used to clone the first sphingosine phosphate lyase gene, BST1. BST1 overexpression conferred resistance to sphingosine in yeast. BST1 deletion produced sensitivity to exogenous D-erythro-sphingosine and phytosphingosine and intracellular accumulation of sphingosine 1-phosphate upon exposure to exogenous sphingosine. This study confirms that sphingoid base metabolism is similar in all eukaryotes and suggests that yeast genetics may be useful in the isolation and identification of other genes involved in sphingolipid signaling and metabolism. << Less
J. Biol. Chem. 272:26087-26090(1997) [PubMed] [EuropePMC]
This publication is cited by 4 other entries.