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- Name help_outline (2Z,4Z)-2-hydroxyhepta-2,4-diene-1,7-dioate Identifier CHEBI:87504 Charge -2 Formula C7H6O5 InChIKeyhelp_outline ZBCBETMBSDTINL-NWJCXACMSA-L SMILEShelp_outline C(=C/C=C(/C([O-])=O)\O)/CC([O-])=O 2D coordinates Mol file for the small molecule Search links Involved in 2 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline (4Z)-2-oxohept-4-enedioate Identifier CHEBI:87507 Charge -2 Formula C7H6O5 InChIKeyhelp_outline ICGKEQXHPZUYSF-UPHRSURJSA-L SMILEShelp_outline C(=C\CC(C([O-])=O)=O)\CC([O-])=O 2D coordinates Mol file for the small molecule Search links Involved in 3 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
Cross-references
| RHEA:38035 | RHEA:38036 | RHEA:38037 | RHEA:38038 | |
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| Reaction direction help_outline | undefined | left-to-right | right-to-left | bidirectional |
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Publications
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Identification and purification of distinct isomerase and decarboxylase enzymes involved in the 4-hydroxyphenylacetate catabolic pathway of Escherichia coli.
Garrido-Peritierra A., Cooper R.A.
The possible involvement of an isomerase in the 4-hydroxyphenylacetate meta-cleavage pathway has been studied. 5-Carboxymethyl-2-hydroxymuconate has been shown to undergo both spontaneous and enzyme-catalysed isomerisation to give 5-carboxymethyl-2-oxo-hex-3-ene-1,5-dioate, a compound with an abso ... >> More
The possible involvement of an isomerase in the 4-hydroxyphenylacetate meta-cleavage pathway has been studied. 5-Carboxymethyl-2-hydroxymuconate has been shown to undergo both spontaneous and enzyme-catalysed isomerisation to give 5-carboxymethyl-2-oxo-hex-3-ene-1,5-dioate, a compound with an absorbance maximum at 246 nm. The latter compound rather than the former is the substrate for a decarboxylase that produces 2-hydroxyhepta-2,4-diene,1,7-dioate. The isomerase and decarboxylase enzymes have been purified to over 90% homogeneity. Mg2+ is required for the decarboxylase reaction but not for the isomerase. << Less
Eur J Biochem 117:581-584(1981) [PubMed] [EuropePMC]
This publication is cited by 4 other entries.
Comments
RHEA:38035 part of RHEA:14397 Published in: Johnson, W.H.; Hajipour, G.; Whitman, C.P. Stereochemical studies of 5-(carboxymethyl)-2-hydroxymuconate isomerase and 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dioate decarboxylase from Escherichia coli C: mechanistic and evolutionary implications. J. Am. Chem. Soc. 117, 8719-8726 (1995)