Reaction participants Show >> << Hide
- Name help_outline 1,2,3-tri-(9Z-octadecenoyl)-glycerol Identifier CHEBI:53753 (Beilstein: 1718692; CAS: 122-32-7) help_outline Charge 0 Formula C57H104O6 InChIKeyhelp_outline PHYFQTYBJUILEZ-IUPFWZBJSA-N SMILEShelp_outline CCCCCCCC\C=C/CCCCCCCC(=O)OCC(COC(=O)CCCCCCC\C=C/CCCCCCCC)OC(=O)CCCCCCC\C=C/CCCCCCCC 2D coordinates Mol file for the small molecule Search links Involved in 17 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline all-trans-retinol Identifier CHEBI:17336 (Beilstein: 403040; CAS: 68-26-8,11103-57-4) help_outline Charge 0 Formula C20H30O InChIKeyhelp_outline FPIPGXGPPPQFEQ-OVSJKPMPSA-N SMILEShelp_outline C\C(=C/CO)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C 2D coordinates Mol file for the small molecule Search links Involved in 29 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline all-trans-retinyl 9Z-octadecenoate Identifier CHEBI:70760 (CAS: 631-88-9) help_outline Charge 0 Formula C38H62O2 InChIKeyhelp_outline FXKDHZXYYBPLHI-TUTABMRPSA-N SMILEShelp_outline CCCCCCCC\C=C/CCCCCCCC(=O)OC\C=C(C)\C=C\C=C(C)\C=C\C1=C(C)CCCC1(C)C 2D coordinates Mol file for the small molecule Search links Involved in 1 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline di-(9Z)-octadecenoylglycerol Identifier CHEBI:75945 Charge 0 Formula C39H72O5 SMILEShelp_outline O(C(CO*)COC(CCCCCCC/C=C\CCCCCCCC)=O)* 2D coordinates Mol file for the small molecule Search links Involved in 60 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
Cross-references
RHEA:39987 | RHEA:39988 | RHEA:39989 | RHEA:39990 | |
---|---|---|---|---|
Reaction direction help_outline | undefined | left-to-right | right-to-left | bidirectional |
UniProtKB help_outline |
|
Related reactions help_outline
More general form(s) of this reaction
Publications
-
A comparative study of human GS2, its paralogues, and its rat orthologue.
Gao J.G., Simon M.
We have previously shown that human GS2 (hGS2) catalyzes keratinocyte retinylester and triglyceride hydrolysis. hGS2 and its rat orthologue, rGS2, are 80% homologous and share a proline insertion at residue 56 and a C-terminal truncation compared to the hGS2 paralogues. Both changes are required f ... >> More
We have previously shown that human GS2 (hGS2) catalyzes keratinocyte retinylester and triglyceride hydrolysis. hGS2 and its rat orthologue, rGS2, are 80% homologous and share a proline insertion at residue 56 and a C-terminal truncation compared to the hGS2 paralogues. Both changes are required for hGS2 function. However, the catalytic capabilities of hGS2 are more similar to the paralogue, TTS-2.2, than to rGS2. Only hGS2 and hTTS-2.2 transfer fatty acid from triglyceride to retinol, hydrolyze retinylesters, and generate 1,3-diacylglycerol from triglycerides. Rat-human chimeras containing either the N- or C-terminus of rGS2 are without activity and single substitutions of rat for human residues cause activity loss. The differences between orthologues suggest that GS2 has a unique function in humans or has a function that is fulfilled by other enzymes in rodents. Since retinoid and triglyceride metabolites are transcription factor ligands, we expect that these enzymes will coordinately regulate epidermal homeostasis. << Less
Biochem. Biophys. Res. Commun. 360:501-506(2007) [PubMed] [EuropePMC]
This publication is cited by 2 other entries.