Enzymes
UniProtKB help_outline | 1,292 proteins |
Reaction participants Show >> << Hide
- Name help_outline an N-(acyl)-sphingosylphosphocholine Identifier CHEBI:64583 Charge 0 Formula C9H19N2O6PR2 SMILEShelp_outline C[N+](C)(C)CCOP([O-])(=O)OC[C@H](NC([*])=O)[C@H](O)[*] 2D coordinates Mol file for the small molecule Search links Involved in 28 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
Cross-references
RHEA:43776 | RHEA:43777 | RHEA:43778 | RHEA:43779 | |
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Reaction direction help_outline | undefined | left-to-right | right-to-left | bidirectional |
UniProtKB help_outline |
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Related reactions help_outline
Specific form(s) of this reaction
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RHEA:39727
a sphingomyelin(in) = a sphingomyelin(out)
Publications
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An isoform of the phosphatidylinositol-transfer protein transfers sphingomyelin and is associated with the Golgi system.
de Vries K.J., Heinrichs A.A., Cunningham E., Brunink F., Westerman J., Somerharju P.J., Cockcroft S., Wirtz K.W., Snoek G.T.
An isoform of the phosphatidylinositol-transfer protein (PI-TP) was identified in the cytosol fraction of bovine brain. This protein, designated PI-TP beta, has an apparent molecular mass of 36 kDa and an isoelectric point of 5.4. The N-terminal amino acid sequence (21 residues) is 90% similar to ... >> More
An isoform of the phosphatidylinositol-transfer protein (PI-TP) was identified in the cytosol fraction of bovine brain. This protein, designated PI-TP beta, has an apparent molecular mass of 36 kDa and an isoelectric point of 5.4. The N-terminal amino acid sequence (21 residues) is 90% similar to that of bovine brain PI-TP, henceforth designated PI-TP alpha (molecular mass 35 kDa and pI 5.5). As observed for PI-TP alpha, PI-TP beta has a distinct preference for phosphatidylinositol over phosphatidylcholine. In addition, it expresses a high transfer activity towards sphingomyelin. PI-TP alpha lacks this activity completely. By indirect immunofluorescence we demonstrated that, in Swiss mouse 3T3 fibroblasts, PI-TP beta is preferentially associated with the Golgi system whereas PI-TP alpha is predominantly present in the cytoplasm and the nucleus. In cytosol-depleted HL60 cells, both PI-TP alpha and PI-TP beta were equally effective at reconstituting guanosine 5'-[gamma-thio]triphosphate-mediated phospholipase C beta activity. << Less
Biochem. J. 310:643-649(1995) [PubMed] [EuropePMC]
This publication is cited by 2 other entries.