Enzymes
UniProtKB help_outline | 5 proteins |
Reaction participants Show >> << Hide
- Name help_outline a triacylglycerol Identifier CHEBI:17855 Charge 0 Formula C6H5O6R3 SMILEShelp_outline [*]C(=O)OCC(COC([*])=O)OC([*])=O 2D coordinates Mol file for the small molecule Search links Involved in 131 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline all-trans-retinol Identifier CHEBI:17336 (Beilstein: 403040; CAS: 68-26-8,11103-57-4) help_outline Charge 0 Formula C20H30O InChIKeyhelp_outline FPIPGXGPPPQFEQ-OVSJKPMPSA-N SMILEShelp_outline C\C(=C/CO)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C 2D coordinates Mol file for the small molecule Search links Involved in 29 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline a diacylglycerol Identifier CHEBI:18035 Charge 0 Formula C5H6O5R2 SMILEShelp_outline [*]OCC(CO[*])O[*] 2D coordinates Mol file for the small molecule Search links Involved in 378 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline an all-trans-retinyl ester Identifier CHEBI:63410 Charge 0 Formula C21H29O2R SMILEShelp_outline CC(\C=C\C=C(C)\C=C\C1=C(C)CCCC1(C)C)=C/COC([*])=O 2D coordinates Mol file for the small molecule Search links Involved in 19 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
Cross-references
RHEA:44676 | RHEA:44677 | RHEA:44678 | RHEA:44679 | |
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Reaction direction help_outline | undefined | left-to-right | right-to-left | bidirectional |
UniProtKB help_outline |
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Related reactions help_outline
Specific form(s) of this reaction
Publications
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A comparative study of human GS2, its paralogues, and its rat orthologue.
Gao J.G., Simon M.
We have previously shown that human GS2 (hGS2) catalyzes keratinocyte retinylester and triglyceride hydrolysis. hGS2 and its rat orthologue, rGS2, are 80% homologous and share a proline insertion at residue 56 and a C-terminal truncation compared to the hGS2 paralogues. Both changes are required f ... >> More
We have previously shown that human GS2 (hGS2) catalyzes keratinocyte retinylester and triglyceride hydrolysis. hGS2 and its rat orthologue, rGS2, are 80% homologous and share a proline insertion at residue 56 and a C-terminal truncation compared to the hGS2 paralogues. Both changes are required for hGS2 function. However, the catalytic capabilities of hGS2 are more similar to the paralogue, TTS-2.2, than to rGS2. Only hGS2 and hTTS-2.2 transfer fatty acid from triglyceride to retinol, hydrolyze retinylesters, and generate 1,3-diacylglycerol from triglycerides. Rat-human chimeras containing either the N- or C-terminus of rGS2 are without activity and single substitutions of rat for human residues cause activity loss. The differences between orthologues suggest that GS2 has a unique function in humans or has a function that is fulfilled by other enzymes in rodents. Since retinoid and triglyceride metabolites are transcription factor ligands, we expect that these enzymes will coordinately regulate epidermal homeostasis. << Less
Biochem. Biophys. Res. Commun. 360:501-506(2007) [PubMed] [EuropePMC]
This publication is cited by 2 other entries.