Enzymes
| UniProtKB help_outline | 1,394 proteins |
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Reaction participants Show >> << Hide
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Namehelp_outline
[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester
Identifier
RHEA-COMP:12126
Reactive part
help_outline
- Name help_outline C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester residue Identifier CHEBI:90511 Charge 0 Formula C19H32NO2S SMILEShelp_outline C(=O)(OC)[C@@H](N*)CSC/C=C(/CC/C=C(/CCC=C(C)C)\C)\C 2D coordinates Mol file for the small molecule Search links Involved in 2 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline H2O Identifier CHEBI:15377 (CAS: 7732-18-5) help_outline Charge 0 Formula H2O InChIKeyhelp_outline XLYOFNOQVPJJNP-UHFFFAOYSA-N SMILEShelp_outline [H]O[H] 2D coordinates Mol file for the small molecule Search links Involved in 6,485 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
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Namehelp_outline
[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine
Identifier
RHEA-COMP:12125
Reactive part
help_outline
- Name help_outline C-terminal S-[(2E,6E)-farnesyl]-L-cysteine residue Identifier CHEBI:90510 Charge -1 Formula C18H29NO2S SMILEShelp_outline C(=O)([O-])[C@@H](N*)CSC/C=C(/CC/C=C(/CCC=C(C)C)\C)\C 2D coordinates Mol file for the small molecule Search links Involved in 2 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline methanol Identifier CHEBI:17790 (CAS: 67-56-1) help_outline Charge 0 Formula CH4O InChIKeyhelp_outline OKKJLVBELUTLKV-UHFFFAOYSA-N SMILEShelp_outline CO 2D coordinates Mol file for the small molecule Search links Involved in 47 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline H+ Identifier CHEBI:15378 Charge 1 Formula H InChIKeyhelp_outline GPRLSGONYQIRFK-UHFFFAOYSA-N SMILEShelp_outline [H+] 2D coordinates Mol file for the small molecule Search links Involved in 9,932 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
Cross-references
| RHEA:48520 | RHEA:48521 | RHEA:48522 | RHEA:48523 | |
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| Reaction direction help_outline | undefined | left-to-right | right-to-left | bidirectional |
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Publications
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Prenylcysteine methylesterase in Arabidopsis thaliana.
Deem A.K., Bultema R.L., Crowell D.N.
Prenylated proteins undergo a series of post-translational modifications, including prenylation, proteolysis, and methylation. Collectively, these modifications generate a prenylcysteine methylester at the carboxyl terminus and modulate protein targeting and function. Prenylcysteine methylation is ... >> More
Prenylated proteins undergo a series of post-translational modifications, including prenylation, proteolysis, and methylation. Collectively, these modifications generate a prenylcysteine methylester at the carboxyl terminus and modulate protein targeting and function. Prenylcysteine methylation is the only reversible step in this series of modifications. However, prenylcysteine alpha-carboxyl methylesterase (PCME) activity has not been described in plants. We have detected a specific PCME activity in Arabidopsis thaliana membranes that discriminates between biologically relevant and irrelevant prenylcysteine methylester substrates. Furthermore, we have identified an Arabidopsis gene (At5g15860) that encodes measurable PCME activity in recombinant yeast cells with greater specificity for biologically relevant prenylcysteine methylesters than the activity found in Arabidopsis membranes. These results suggest that specific and non-specific esterases catalyze the demethylation of prenylcysteine methylesters in Arabidopsis membranes. Our findings are discussed in the context of prenylcysteine methylation/demethylation as a potential regulatory mechanism for membrane association and function of prenylated proteins in Arabidopsis. << Less