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- Name help_outline Fe(III)-heme b Identifier CHEBI:55376 Charge -1 Formula C34H30FeN4O4 InChIKeyhelp_outline GGIDWJQWCUJYRY-RGGAHWMASA-J SMILEShelp_outline CC1=C(CCC([O-])=O)C2=[N+]3C1=Cc1c(C)c(C=C)c4C=C5C(C)=C(C=C)C6=[N+]5[Fe-]3(n14)n1c(=C6)c(C)c(CCC([O-])=O)c1=C2 2D coordinates Mol file for the small molecule Search links Involved in 5 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline β-hematin Identifier CHEBI:55377 Charge -2 Formula C68H60Fe2N8O8 InChIKeyhelp_outline HXEIDFYYVJVSGW-AWOXZACZSA-F SMILEShelp_outline C1=2N3C(C=C4[N+]5=C(C=C6N7C8=CC9=[N+](C(=C1)C(=C9CCC([O-])=O)C)[Fe-2]573OC(CCC=%10C=%11C=C%12C(=C(C%13=CC%14=[N+]%15C(=CC=%16N%17C(=C(C%16C=C)C)C=C([N+]%11[Fe-2]%15%17(N%13%12)OC(CCC8=C6C)=O)C%10C)C(=C%14C=C)C)C)CCC([O-])=O)=O)C(=C4C)C=C)=C(C2C)C=C 2D coordinates Mol file for the small molecule Search links Involved in 1 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
Cross-references
| RHEA:53712 | RHEA:53713 | RHEA:53714 | RHEA:53715 | |
|---|---|---|---|---|
| Reaction direction help_outline | undefined | left-to-right | right-to-left | bidirectional |
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Publications
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HDP-a novel heme detoxification protein from the malaria parasite.
Jani D., Nagarkatti R., Beatty W., Angel R., Slebodnick C., Andersen J., Kumar S., Rathore D.
When malaria parasites infect host red blood cells (RBC) and proteolyze hemoglobin, a unique, albeit poorly understood parasite-specific mechanism, detoxifies released heme into hemozoin (Hz). Here, we report the identification and characterization of a novel Plasmodium Heme Detoxification Protein ... >> More
When malaria parasites infect host red blood cells (RBC) and proteolyze hemoglobin, a unique, albeit poorly understood parasite-specific mechanism, detoxifies released heme into hemozoin (Hz). Here, we report the identification and characterization of a novel Plasmodium Heme Detoxification Protein (HDP) that is extremely potent in converting heme into Hz. HDP is functionally conserved across Plasmodium genus and its gene locus could not be disrupted. Once expressed, the parasite utilizes a circuitous "Outbound-Inbound" trafficking route by initially secreting HDP into the cytosol of infected RBC. A subsequent endocytosis of host cytosol (and hemoglobin) delivers HDP to the food vacuole (FV), the site of Hz formation. As Hz formation is critical for survival, involvement of HDP in this process suggests that it could be a malaria drug target. << Less