Enzymes
UniProtKB help_outline | 1 proteins |
Reaction participants Show >> << Hide
- Name help_outline 1,2-diheptanoyl-sn-glycero-3-phosphocholine Identifier CHEBI:138195 (CAS: 39036-04-9) help_outline Charge 0 Formula C22H44NO8P InChIKeyhelp_outline RBFSPQDASPEAID-HXUWFJFHSA-N SMILEShelp_outline P(OC[C@@H](COC(CCCCCC)=O)OC(=O)CCCCCC)(=O)(OCC[N+](C)(C)C)[O-] 2D coordinates Mol file for the small molecule Search links Involved in 4 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline 1,2-dihexanoyl-sn-glycero-3-phosphoethanolamine Identifier CHEBI:138216 Charge 0 Formula C17H34NO8P InChIKeyhelp_outline PELYUHWUVHDSSU-OAHLLOKOSA-N SMILEShelp_outline C(C[NH3+])OP(OC[C@@H](COC(CCCCC)=O)OC(=O)CCCCC)(=O)[O-] 2D coordinates Mol file for the small molecule Search links Involved in 2 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline 1-heptanoyl-2-hexanoyl-sn-glycero-3-phosphoethanolamine Identifier CHEBI:138217 Charge 0 Formula C18H36NO8P InChIKeyhelp_outline BVSONJOGLYNESH-MRXNPFEDSA-N SMILEShelp_outline C(C[NH3+])OP(OC[C@@H](COC(CCCCCC)=O)OC(=O)CCCCC)(=O)[O-] 2D coordinates Mol file for the small molecule Search links Involved in 1 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline 1-hexanoyl-2-heptanoyl-sn-glycero-3-phosphocholine Identifier CHEBI:138197 Charge 0 Formula C21H42NO8P InChIKeyhelp_outline FKCJGWFCANEGLV-LJQANCHMSA-N SMILEShelp_outline P(OC[C@@H](COC(CCCCC)=O)OC(=O)CCCCCC)(=O)(OCC[N+](C)(C)C)[O-] 2D coordinates Mol file for the small molecule Search links Involved in 3 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
Cross-references
RHEA:54492 | RHEA:54493 | RHEA:54494 | RHEA:54495 | |
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Reaction direction help_outline | undefined | left-to-right | right-to-left | bidirectional |
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Publications
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Structural basis for the acyltransferase activity of lecithin:retinol acyltransferase-like proteins.
Golczak M., Kiser P.D., Sears A.E., Lodowski D.T., Blaner W.S., Palczewski K.
Lecithin:retinol acyltransferase-like proteins, also referred to as HRAS-like tumor suppressors, comprise a vertebrate subfamily of papain-like or NlpC/P60 thiol proteases that function as phospholipid-metabolizing enzymes. HRAS-like tumor suppressor 3, a representative member of this group, plays ... >> More
Lecithin:retinol acyltransferase-like proteins, also referred to as HRAS-like tumor suppressors, comprise a vertebrate subfamily of papain-like or NlpC/P60 thiol proteases that function as phospholipid-metabolizing enzymes. HRAS-like tumor suppressor 3, a representative member of this group, plays a key role in regulating triglyceride accumulation and energy expenditure in adipocytes and therefore constitutes a novel pharmacological target for treatment of metabolic disorders causing obesity. Here, we delineate a catalytic mechanism common to lecithin:retinol acyltransferase-like proteins and provide evidence for their alternative robust lipid-dependent acyltransferase enzymatic activity. We also determined high resolution crystal structures of HRAS-like tumor suppressor 2 and 3 to gain insight into their active site architecture. Based on this structural analysis, two conformational states of the catalytic Cys-113 were identified that differ in reactivity and thus could define the catalytic properties of these two proteins. Finally, these structures provide a model for the topology of these enzymes and allow identification of the protein-lipid bilayer interface. This study contributes to the enzymatic and structural understanding of HRAS-like tumor suppressor enzymes. << Less
J. Biol. Chem. 287:23790-23807(2012) [PubMed] [EuropePMC]
This publication is cited by 9 other entries.