Reaction participants Show >> << Hide
- Name help_outline trans-4-hydroxy-L-proline Identifier CHEBI:58375 Charge 0 Formula C5H9NO3 InChIKeyhelp_outline PMMYEEVYMWASQN-DMTCNVIQSA-N SMILEShelp_outline O[C@H]1C[NH2+][C@@H](C1)C([O-])=O 2D coordinates Mol file for the small molecule Search links Involved in 5 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline (S)-1-pyrroline-5-carboxylate Identifier CHEBI:17388 Charge -1 Formula C5H6NO2 InChIKeyhelp_outline DWAKNKKXGALPNW-BYPYZUCNSA-M SMILEShelp_outline [O-]C(=O)[C@@H]1CCC=N1 2D coordinates Mol file for the small molecule Search links Involved in 7 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline H+ Identifier CHEBI:15378 Charge 1 Formula H InChIKeyhelp_outline GPRLSGONYQIRFK-UHFFFAOYSA-N SMILEShelp_outline [H+] 2D coordinates Mol file for the small molecule Search links Involved in 9,176 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline H2O Identifier CHEBI:15377 (Beilstein: 3587155; CAS: 7732-18-5) help_outline Charge 0 Formula H2O InChIKeyhelp_outline XLYOFNOQVPJJNP-UHFFFAOYSA-N SMILEShelp_outline [H]O[H] 2D coordinates Mol file for the small molecule Search links Involved in 6,048 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
Cross-references
| RHEA:54644 | RHEA:54645 | RHEA:54646 | RHEA:54647 | |
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| Reaction direction help_outline | undefined | left-to-right | right-to-left | bidirectional |
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Publications
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A prominent glycyl radical enzyme in human gut microbiomes metabolizes trans-4-hydroxy-L-proline.
Levin B.J., Huang Y.Y., Peck S.C., Wei Y., Martinez-Del Campo A., Marks J.A., Franzosa E.A., Huttenhower C., Balskus E.P.
The human microbiome encodes vast numbers of uncharacterized enzymes, limiting our functional understanding of this community and its effects on host health and disease. By incorporating information about enzymatic chemistry into quantitative metagenomics, we determined the abundance and distribut ... >> More
The human microbiome encodes vast numbers of uncharacterized enzymes, limiting our functional understanding of this community and its effects on host health and disease. By incorporating information about enzymatic chemistry into quantitative metagenomics, we determined the abundance and distribution of individual members of the glycyl radical enzyme superfamily among the microbiomes of healthy humans. We identified many uncharacterized family members, including a universally distributed enzyme that enables commensal gut microbes and human pathogens to dehydrate <i>trans</i>-4-hydroxy-l-proline, the product of the most abundant human posttranslational modification. This "chemically guided functional profiling" workflow can therefore use ecological context to facilitate the discovery of enzymes in microbial communities. << Less