Reaction participants Show >> << Hide
- Name help_outline 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine Identifier CHEBI:74986 Charge 0 Formula C41H78NO8P InChIKeyhelp_outline MWRBNPKJOOWZPW-NYVOMTAGSA-N SMILEShelp_outline O(C(=O)CCCCCCC/C=C\CCCCCCCC)[C@H](COC(=O)CCCCCCC/C=C\CCCCCCCC)COP(=O)([O-])OCC[NH3+] 2D coordinates Mol file for the small molecule Search links Involved in 15 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine Identifier CHEBI:76088 Charge 0 Formula C23H46NO7P InChIKeyhelp_outline NOVZJYYJYIFXJC-MZMPXXGTSA-N SMILEShelp_outline CCCCCCCC\C=C/CCCCCCCC(=O)O[C@H](CO)COP([O-])(=O)OCC[NH3+] 2D coordinates Mol file for the small molecule Search links Involved in 5 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline H+ Identifier CHEBI:15378 Charge 1 Formula H InChIKeyhelp_outline GPRLSGONYQIRFK-UHFFFAOYSA-N SMILEShelp_outline [H+] 2D coordinates Mol file for the small molecule Search links Involved in 9,176 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline N,1,2-tri-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine Identifier CHEBI:85291 Charge -1 Formula C59H109NO9P InChIKeyhelp_outline FKSBBLIERCUNPB-WTZXFCJFSA-M SMILEShelp_outline CCCCCCCC\C=C/CCCCCCCC(=O)NCCOP([O-])(=O)OC[C@@H](COC(=O)CCCCCCC\C=C/CCCCCCCC)OC(=O)CCCCCCC\C=C/CCCCCCCC 2D coordinates Mol file for the small molecule Search links Involved in 3 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
Cross-references
| RHEA:55260 | RHEA:55261 | RHEA:55262 | RHEA:55263 | |
|---|---|---|---|---|
| Reaction direction help_outline | undefined | left-to-right | right-to-left | bidirectional |
| UniProtKB help_outline |
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Publications
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A calcium-dependent acyltransferase that produces N-acyl phosphatidylethanolamines.
Ogura Y., Parsons W.H., Kamat S.S., Cravatt B.F.
More than 30 years ago, a calcium-dependent enzyme activity was described that generates N-acyl phosphatidylethanolamines (NAPEs), which are precursors for N-acyl ethanolamine (NAE) lipid transmitters, including the endocannabinoid anandamide. The identity of this calcium-dependent N-acyltransfera ... >> More
More than 30 years ago, a calcium-dependent enzyme activity was described that generates N-acyl phosphatidylethanolamines (NAPEs), which are precursors for N-acyl ethanolamine (NAE) lipid transmitters, including the endocannabinoid anandamide. The identity of this calcium-dependent N-acyltransferase (Ca-NAT) has remained mysterious. Here, we use activity-based protein profiling to identify the poorly characterized serine hydrolase PLA2G4E as a mouse brain Ca-NAT and show that this enzyme generates NAPEs and NAEs in mammalian cells. << Less
Nat. Chem. Biol. 12:669-671(2016) [PubMed] [EuropePMC]
This publication is cited by 4 other entries.