Enzymes
| UniProtKB help_outline | 1 proteins |
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- Name help_outline 1,2-ditetradecanoyl-sn-glycero-3-phosphocholine Identifier CHEBI:45240 (CAS: 18194-24-6) help_outline Charge 0 Formula C36H72NO8P InChIKeyhelp_outline CITHEXJVPOWHKC-UUWRZZSWSA-N SMILEShelp_outline CCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCC 2D coordinates Mol file for the small molecule Search links Involved in 3 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline 1,2-di-(9Z-octadecenoyl)-sn-glycerol Identifier CHEBI:52333 (CAS: 24529-88-2) help_outline Charge 0 Formula C39H72O5 InChIKeyhelp_outline AFSHUZFNMVJNKX-LLWMBOQKSA-N SMILEShelp_outline CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@H](CO)OC(=O)CCCCCCC\C=C/CCCCCCCC 2D coordinates Mol file for the small molecule Search links Involved in 28 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline 1,2-ditetradecanoyl-sn-glycerol Identifier CHEBI:80651 (CAS: 60562-16-5) help_outline Charge 0 Formula C31H60O5 InChIKeyhelp_outline JFBCSFJKETUREV-LJAQVGFWSA-N SMILEShelp_outline C(CCCCCCCC)CCCCC(=O)O[C@@H](CO)COC(CCCCCCCCCCCCC)=O 2D coordinates Mol file for the small molecule Search links Involved in 2 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine Identifier CHEBI:74669 (CAS: 4235-95-4) help_outline Charge 0 Formula C44H84NO8P InChIKeyhelp_outline SNKAWJBJQDLSFF-NVKMUCNASA-N SMILEShelp_outline CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/CCCCCCCC 2D coordinates Mol file for the small molecule Search links Involved in 30 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
Cross-references
| RHEA:56412 | RHEA:56413 | RHEA:56414 | RHEA:56415 | |
|---|---|---|---|---|
| Reaction direction help_outline | undefined | left-to-right | right-to-left | bidirectional |
| UniProtKB help_outline |
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Publications
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An enzyme regulating triacylglycerol composition is encoded by the ROD1 gene of Arabidopsis.
Lu C., Xin Z., Ren Z., Miquel M., Browse J.
The polyunsaturated fatty acids (PUFAs) linoleic acid (18:2) and alpha-linolenic acid (18:3) in triacylglycerols (TAG) are major factors affecting the quality of plant oils for human health, as well as for biofuels and other renewable applications. These PUFAs are essential fatty acids for animals ... >> More
The polyunsaturated fatty acids (PUFAs) linoleic acid (18:2) and alpha-linolenic acid (18:3) in triacylglycerols (TAG) are major factors affecting the quality of plant oils for human health, as well as for biofuels and other renewable applications. These PUFAs are essential fatty acids for animals and plants, but also are the source of unhealthy trans fats during the processing of many foodstuffs. PUFAs 18:2 and 18:3 are synthesized in developing seeds by the desaturation of oleic acid (18:1) esterified on the membrane lipid phosphatidylcholine (PC) on the endoplasmic reticulum. The reactions and fluxes involved in this metabolism are incompletely understood, however. Here we show that a previously unrecognized enzyme, phosphatidylcholine:diacylglycerol cholinephosphotransferase (PDCT), encoded by the Arabidopsis ROD1 gene, is a major reaction for the transfer of 18:1 into PC for desaturation and also for the reverse transfer of 18:2 and 18:3 into the TAG synthesis pathway. The PDCT enzyme catalyzes transfer of the phosphocholine headgroup from PC to diacylglycerol, and mutation of rod1 reduces 18:2 and 18:3 accumulation in seed TAG by 40%. Our discovery of PDCT is important for understanding glycerolipid metabolism in plants and other organisms, and provides tools to modify the fatty acid compositions of plant oils for improved nutrition, biofuel, and other purposes. << Less
Proc. Natl. Acad. Sci. U.S.A. 106:18837-18842(2009) [PubMed] [EuropePMC]