Reaction participants Show >> << Hide
- Name help_outline 2-oxoglutarate Identifier CHEBI:16810 (Beilstein: 3664503; CAS: 64-15-3) help_outline Charge -2 Formula C5H4O5 InChIKeyhelp_outline KPGXRSRHYNQIFN-UHFFFAOYSA-L SMILEShelp_outline [O-]C(=O)CCC(=O)C([O-])=O 2D coordinates Mol file for the small molecule Search links Involved in 418 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
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Namehelp_outline
N6-methyladenosine in U6 snRNA
Identifier
RHEA-COMP:13574
Reactive part
help_outline
- Name help_outline N6-methyladenosine 5'-phosphate residue Identifier CHEBI:74449 Charge -1 Formula C11H13N5O6P SMILEShelp_outline C=1(NC)N=CN=C2C1N=CN2[C@@H]3O[C@H](COP(=O)(*)[O-])[C@@H](O*)[C@H]3O 2D coordinates Mol file for the small molecule Search links Involved in 11 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline O2 Identifier CHEBI:15379 (CAS: 7782-44-7) help_outline Charge 0 Formula O2 InChIKeyhelp_outline MYMOFIZGZYHOMD-UHFFFAOYSA-N SMILEShelp_outline O=O 2D coordinates Mol file for the small molecule Search links Involved in 2,648 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
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Namehelp_outline
adenosine in U6 snRNA
Identifier
RHEA-COMP:13573
Reactive part
help_outline
- Name help_outline AMP residue Identifier CHEBI:74411 Charge -1 Formula C10H11N5O6P SMILEShelp_outline NC1=NC=NC2=C1N=CN2[C@@H]3O[C@H](COP(=O)(*)[O-])[C@@H](O*)[C@H]3O 2D coordinates Mol file for the small molecule Search links Involved in 38 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline CO2 Identifier CHEBI:16526 (Beilstein: 1900390; CAS: 124-38-9) help_outline Charge 0 Formula CO2 InChIKeyhelp_outline CURLTUGMZLYLDI-UHFFFAOYSA-N SMILEShelp_outline O=C=O 2D coordinates Mol file for the small molecule Search links Involved in 980 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline formaldehyde Identifier CHEBI:16842 (Beilstein: 1209228; CAS: 50-00-0) help_outline Charge 0 Formula CH2O InChIKeyhelp_outline WSFSSNUMVMOOMR-UHFFFAOYSA-N SMILEShelp_outline [H]C([H])=O 2D coordinates Mol file for the small molecule Search links Involved in 137 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline succinate Identifier CHEBI:30031 (Beilstein: 1863859; CAS: 56-14-4) help_outline Charge -2 Formula C4H4O4 InChIKeyhelp_outline KDYFGRWQOYBRFD-UHFFFAOYSA-L SMILEShelp_outline [O-]C(=O)CCC([O-])=O 2D coordinates Mol file for the small molecule Search links Involved in 325 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
Cross-references
| RHEA:57900 | RHEA:57901 | RHEA:57902 | RHEA:57903 | |
|---|---|---|---|---|
| Reaction direction help_outline | undefined | left-to-right | right-to-left | bidirectional |
| UniProtKB help_outline |
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Publications
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Differential m6A, m6Am, and m1A demethylation mediated by FTO in the cell nucleus and cytoplasm.
Wei J., Liu F., Lu Z., Fei Q., Ai Y., He P.C., Shi H., Cui X., Su R., Klungland A., Jia G., Chen J., He C.
FTO, the first RNA demethylase discovered, mediates the demethylation of internal N<sup>6</sup>-methyladenosine (m<sup>6</sup>A) and N<sup>6</sup>, 2-O-dimethyladenosine (m<sup>6</sup>A<sub>m</sub>) at the +1 position from the 5' cap in mRNA. Here we demonstrate that the cellular distribution of F ... >> More
FTO, the first RNA demethylase discovered, mediates the demethylation of internal N<sup>6</sup>-methyladenosine (m<sup>6</sup>A) and N<sup>6</sup>, 2-O-dimethyladenosine (m<sup>6</sup>A<sub>m</sub>) at the +1 position from the 5' cap in mRNA. Here we demonstrate that the cellular distribution of FTO is distinct among different cell lines, affecting the access of FTO to different RNA substrates. We find that FTO binds multiple RNA species, including mRNA, snRNA, and tRNA, and can demethylate internal m<sup>6</sup>A and cap m<sup>6</sup>A<sub>m</sub> in mRNA, internal m<sup>6</sup>A in U6 RNA, internal and cap m<sup>6</sup>A<sub>m</sub> in snRNAs, and N<sup>1</sup>-methyladenosine (m<sup>1</sup>A) in tRNA. FTO-mediated demethylation has a greater effect on the transcript levels of mRNAs possessing internal m<sup>6</sup>A than the ones with cap m<sup>6</sup>A<sub>m</sub> in the tested cells. We also show that FTO can directly repress translation by catalyzing m<sup>1</sup>A tRNA demethylation. Collectively, FTO-mediated RNA demethylation occurs to m<sup>6</sup>A and m<sup>6</sup>A<sub>m</sub> in mRNA and snRNA as well as m<sup>1</sup>A in tRNA. << Less
Mol. Cell 71:973-985(2018) [PubMed] [EuropePMC]
This publication is cited by 1 other entry.