Enzymes
Enzyme class help_outline |
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Reaction participants Show >> << Hide
- Name help_outline demethylluteothin Identifier CHEBI:142870 Charge -1 Formula C21H22NO5 InChIKeyhelp_outline TWLUULBJSDGQQK-PHEQNACWSA-M SMILEShelp_outline C1=CC(=CC=C1/C=C(/C=C(/CCC2=C(C(C(=C(O2)[O-])C)=O)C)\C)\C)[N+]([O-])=O 2D coordinates Mol file for the small molecule Search links Involved in 2 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline S-adenosyl-L-methionine Identifier CHEBI:59789 Charge 1 Formula C15H23N6O5S InChIKeyhelp_outline MEFKEPWMEQBLKI-AIRLBKTGSA-O SMILEShelp_outline C[S+](CC[C@H]([NH3+])C([O-])=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12 2D coordinates Mol file for the small molecule Search links Involved in 842 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline luteothin Identifier CHEBI:142840 Charge 0 Formula C22H25NO5 InChIKeyhelp_outline QJCZWAGFDPHLHZ-QUMQEAAQSA-N SMILEShelp_outline C1=CC(=CC=C1/C=C(/C=C(/CCC2=C(C(C(=C(O2)OC)C)=O)C)\C)\C)[N+]([O-])=O 2D coordinates Mol file for the small molecule Search links Involved in 2 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline S-adenosyl-L-homocysteine Identifier CHEBI:57856 Charge 0 Formula C14H20N6O5S InChIKeyhelp_outline ZJUKTBDSGOFHSH-WFMPWKQPSA-N SMILEShelp_outline Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CSCC[C@H]([NH3+])C([O-])=O)[C@@H](O)[C@H]1O 2D coordinates Mol file for the small molecule Search links Involved in 768 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
Cross-references
RHEA:59064 | RHEA:59065 | RHEA:59066 | RHEA:59067 | |
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Reaction direction help_outline | undefined | left-to-right | right-to-left | bidirectional |
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Publications
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Formation of the aureothin tetrahydrofuran ring by a bifunctional cytochrome p450 monooxygenase.
He J., Muller M., Hertweck C.
The polyketide antibiotic aureothin, produced by Streptomyces thioluteus, is equipped with a rare exomethylene-tetrahydrofuran moiety. Cloning, heterologous expression, and inactivation experiments reveal that AurH, a bifunctional cytochrome P450 monooxygenase, is required and sufficient for the s ... >> More
The polyketide antibiotic aureothin, produced by Streptomyces thioluteus, is equipped with a rare exomethylene-tetrahydrofuran moiety. Cloning, heterologous expression, and inactivation experiments reveal that AurH, a bifunctional cytochrome P450 monooxygenase, is required and sufficient for the stereoselective synthesis of the furan ring, involving the subsequent formation of two new C-O bonds. << Less
J Am Chem Soc 126:16742-16743(2004) [PubMed] [EuropePMC]
This publication is cited by 2 other entries.
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Dissection of the late steps in aureothin biosynthesis.
Muller M., He J., Hertweck C.
Chembiochem 7:37-39(2006) [PubMed] [EuropePMC]
This publication is cited by 1 other entry.