Reaction participants Show >> << Hide
- Name help_outline hydrogencarbonate Identifier CHEBI:17544 (Beilstein: 3903504; CAS: 71-52-3) help_outline Charge -1 Formula CHO3 InChIKeyhelp_outline BVKZGUZCCUSVTD-UHFFFAOYSA-M SMILEShelp_outline OC([O-])=O 2D coordinates Mol file for the small molecule Search links Involved in 58 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline selenite Identifier CHEBI:18212 (CAS: 14124-67-5) help_outline Charge -2 Formula O3Se InChIKeyhelp_outline MCAHWIHFGHIESP-UHFFFAOYSA-L SMILEShelp_outline [O-][Se]([O-])=O 2D coordinates Mol file for the small molecule Search links Involved in 7 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline Zn2+ Identifier CHEBI:29105 (CAS: 23713-49-7) help_outline Charge 2 Formula Zn InChIKeyhelp_outline PTFCDOFLOPIGGS-UHFFFAOYSA-N SMILEShelp_outline [Zn++] 2D coordinates Mol file for the small molecule Search links Involved in 8 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
Cross-references
| RHEA:62264 | RHEA:62265 | RHEA:62266 | RHEA:62267 | |
|---|---|---|---|---|
| Reaction direction help_outline | undefined | left-to-right | right-to-left | bidirectional |
| UniProtKB help_outline |
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Publications
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Zinc- and bicarbonate-dependent ZIP8 transporter mediates selenite uptake.
McDermott J.R., Geng X., Jiang L., Galvez-Peralta M., Chen F., Nebert D.W., Liu Z.
Selenite (HSeO3-) is a monovalent anion of the essential trace element and micronutrient selenium (Se). In therapeutic concentrations, HSeO3-has been studied for treating certain cancers, serious inflammatory disorders, and septic shock. Little is known, however, about HSeO3-uptake into mammalian ... >> More
Selenite (HSeO3-) is a monovalent anion of the essential trace element and micronutrient selenium (Se). In therapeutic concentrations, HSeO3-has been studied for treating certain cancers, serious inflammatory disorders, and septic shock. Little is known, however, about HSeO3-uptake into mammalian cells; until now, no mammalian HSeO3-uptake transporter has been identified. The ubiquitous mammalian ZIP8 divalent cation transporter (encoded by the SLC39A8 gene) is bicarbonate-dependent, moving endogenous substrates (Zn2+, Mn2+, Fe2+ or Co2+) and nonessential metals such as Cd2+ into the cell. Herein we studied HSeO3-uptake in: human and mouse cell cultures, shRNA-knockdown experiments, Xenopus oocytes, wild-type mice and two transgenic mouse lines having genetically altered ZIP8 expression, and mouse erythrocytes ex vivo. In mammalian cell culture, excess Zn2+ levels and/or ZIP8 over-expression can be associated with diminished viability in selenite-treated cells. Intraperitoneal HSeO3-causes the largest ZIP8-dependent increases in intracellular Se content in liver, followed by kidney, heart, lung and spleen. In every model system studied, HSeO3-uptake is tightly associated with ZIP8 protein levels and sufficient Zn2+ and HCO3-concentrations, suggesting that the ZIP8-mediated electroneutral complex transported contains three ions: Zn2+/(HCO3-)(HSeO3-). Transporters having three different ions in their transport complex are not without precedent. Although there might be other HSeO3-influx transporters as yet undiscovered, data herein suggest that mammalian ZIP8 plays a major role in HSeO3- uptake. << Less
Oncotarget 7:35327-35340(2016) [PubMed] [EuropePMC]
This publication is cited by 1 other entry.