Enzymes
| UniProtKB help_outline | 1,804 proteins |
| GO Molecular Function help_outline |
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Reaction participants Show >> << Hide
- Name help_outline dopamine Identifier CHEBI:59905 Charge 1 Formula C8H12NO2 InChIKeyhelp_outline VYFYYTLLBUKUHU-UHFFFAOYSA-O SMILEShelp_outline [NH3+]CCc1ccc(O)c(O)c1 2D coordinates Mol file for the small molecule Search links Involved in 26 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
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Namehelp_outline
L-glutaminyl-[protein]
Identifier
RHEA-COMP:10207
Reactive part
help_outline
- Name help_outline L-glutamine residue Identifier CHEBI:30011 Charge 0 Formula C5H8N2O2 SMILEShelp_outline O=C(*)[C@@H](N*)CCC(=O)N 2D coordinates Mol file for the small molecule Search links Involved in 12 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
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Namehelp_outline
5-dopaminyl-L-glutamyl-[protein]
Identifier
RHEA-COMP:17053
Reactive part
help_outline
- Name help_outline N-[2-(3,4-dihydroxyphenyl)ethyl]-L-glutamine residue Identifier CHEBI:167175 Charge 0 Formula C13H16N2O4 SMILEShelp_outline O=C(*)[C@@H](N*)CCC(=O)NCCC1=CC(=C(C=C1)O)O 2D coordinates Mol file for the small molecule Search links Involved in 1 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline NH4+ Identifier CHEBI:28938 (CAS: 14798-03-9) help_outline Charge 1 Formula H4N InChIKeyhelp_outline QGZKDVFQNNGYKY-UHFFFAOYSA-O SMILEShelp_outline [H][N+]([H])([H])[H] 2D coordinates Mol file for the small molecule Search links Involved in 518 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
Cross-references
| RHEA:66556 | RHEA:66557 | RHEA:66558 | RHEA:66559 | |
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| Reaction direction help_outline | undefined | left-to-right | right-to-left | bidirectional |
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| Gene Ontology help_outline |
Publications
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Dopaminylation of histone H3 in ventral tegmental area regulates cocaine seeking.
Lepack A.E., Werner C.T., Stewart A.F., Fulton S.L., Zhong P., Farrelly L.A., Smith A.C.W., Ramakrishnan A., Lyu Y., Bastle R.M., Martin J.A., Mitra S., O'Connor R.M., Wang Z.J., Molina H., Turecki G., Shen L., Yan Z., Calipari E.S., Dietz D.M., Kenny P.J., Maze I.
Vulnerability to relapse during periods of attempted abstinence from cocaine use is hypothesized to result from the rewiring of brain reward circuitries, particularly ventral tegmental area (VTA) dopamine neurons. How cocaine exposures act on midbrain dopamine neurons to precipitate addiction-rele ... >> More
Vulnerability to relapse during periods of attempted abstinence from cocaine use is hypothesized to result from the rewiring of brain reward circuitries, particularly ventral tegmental area (VTA) dopamine neurons. How cocaine exposures act on midbrain dopamine neurons to precipitate addiction-relevant changes in gene expression is unclear. We found that histone H3 glutamine 5 dopaminylation (H3Q5dop) plays a critical role in cocaine-induced transcriptional plasticity in the midbrain. Rats undergoing withdrawal from cocaine showed an accumulation of H3Q5dop in the VTA. By reducing H3Q5dop in the VTA during withdrawal, we reversed cocaine-mediated gene expression changes, attenuated dopamine release in the nucleus accumbens, and reduced cocaine-seeking behavior. These findings establish a neurotransmission-independent role for nuclear dopamine in relapse-related transcriptional plasticity in the VTA. << Less
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Transglutaminase-mediated transamidation of serotonin, dopamine and noradrenaline to fibronectin: evidence for a general mechanism of monoaminylation.
Hummerich R., Thumfart J.O., Findeisen P., Bartsch D., Schloss P.
The activity of some small GTPases is regulated by covalent transamidation of serotonin (5-hydropxytryptamien) to glutamine residues of the enzymes. This process is mediated by transglutaminase (TGase) and is termed "serotonylation". In addition, serotonylation of neural proteins and proteins of t ... >> More
The activity of some small GTPases is regulated by covalent transamidation of serotonin (5-hydropxytryptamien) to glutamine residues of the enzymes. This process is mediated by transglutaminase (TGase) and is termed "serotonylation". In addition, serotonylation of neural proteins and proteins of the extracellular matrix such as fibronectin has been demonstrated. Here we show that the catecholamines dopamine (DA) and noradrenaline (NA) inhibit serotonylation of fibronectin and that DA and NA themselves can be selectively transamidated into fibronectin by TGase. All three biogenic monoamines also block TGase-mediated transamidation of another monoamine, monodansylacadaverine, into fibronectin, suggesting a general mechanism of TGase-mediated "monoaminylation". << Less
FEBS Lett. 586:3421-3428(2012) [PubMed] [EuropePMC]
This publication is cited by 2 other entries.