Enzymes
| UniProtKB help_outline | 2 proteins |
Reaction participants Show >> << Hide
- Name help_outline (2E,6E,10E,14E)-geranylfarnesyl diphosphate Identifier CHEBI:57907 Charge -3 Formula C25H41O7P2 InChIKeyhelp_outline JMVSBFJBMXQNJW-GIXZANJISA-K SMILEShelp_outline CC(C)=CCC\C(C)=C\CC\C(C)=C\CC\C(C)=C\CC\C(C)=C\COP([O-])(=O)OP([O-])([O-])=O 2D coordinates Mol file for the small molecule Search links Involved in 18 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline diphosphate Identifier CHEBI:33019 (Beilstein: 185088) help_outline Charge -3 Formula HO7P2 InChIKeyhelp_outline XPPKVPWEQAFLFU-UHFFFAOYSA-K SMILEShelp_outline OP([O-])(=O)OP([O-])([O-])=O 2D coordinates Mol file for the small molecule Search links Involved in 1,085 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline preasperterpenoid A Identifier CHEBI:167511 Charge 0 Formula C25H40 InChIKeyhelp_outline LJBOQHBHJKFMQV-OMNLMRHKSA-N SMILEShelp_outline [C@]12([C@]([C@@]3([C@@]4([C@]([C@]5(C(C[C@]3(CC1)C)=C(CC5)C)[H])(C4)C)[H])[H])([C@H](CC2)C(C)C)[H])C 2D coordinates Mol file for the small molecule Search links Involved in 2 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
Cross-references
| RHEA:66832 | RHEA:66833 | RHEA:66834 | RHEA:66835 | |
|---|---|---|---|---|
| Reaction direction help_outline | undefined | left-to-right | right-to-left | bidirectional |
| UniProtKB help_outline |
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Publications
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Biosynthesis of an anti-tuberculosis sesterterpenoid asperterpenoid A.
Huang J.H., Lv J.M., Wang Q.Z., Zou J., Lu Y.J., Wang Q.L., Chen D.N., Yao X.S., Gao H., Hu D.
A putative three-gene cluster for asperterpenoid A was identified. Step-wise reconstitution of this gene cluster in Aspergillus oryzae reveals that astC encodes a sesterterpene cyclase to synthesize preasperterpenoid A, which is dually oxidized by a P450 enzyme AstB to give asperterpenoid A along ... >> More
A putative three-gene cluster for asperterpenoid A was identified. Step-wise reconstitution of this gene cluster in Aspergillus oryzae reveals that astC encodes a sesterterpene cyclase to synthesize preasperterpenoid A, which is dually oxidized by a P450 enzyme AstB to give asperterpenoid A along with a minor product asperterpenoid B, and asperterpenoid A is further oxidized by another P450 eznyme AstA to afford a new sesterterpenoid asperterpenoid C. Unexpectedly, asperterpenoids A and B, but not the final product asperterpenoid C, exhibit potent inhibitory activity against Mycobacterium tuberculosis protein tyrosine phosphatase B with IC50 values of 3-6 μM. << Less
Org. Biomol. Chem. 17:248-251(2019) [PubMed] [EuropePMC]
This publication is cited by 3 other entries.