Enzymes
UniProtKB help_outline | 3,181 proteins |
Reaction participants Show >> << Hide
- Name help_outline a hydroperoxide Identifier CHEBI:35924 Charge 0 Formula HO2R SMILEShelp_outline OO[*] 2D coordinates Mol file for the small molecule Search links Involved in 34 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
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Namehelp_outline
L-cysteinyl-[protein]
Identifier
RHEA-COMP:10131
Reactive part
help_outline
- Name help_outline L-cysteine residue Identifier CHEBI:29950 Charge 0 Formula C3H5NOS SMILEShelp_outline C(=O)(*)[C@@H](N*)CS 2D coordinates Mol file for the small molecule Search links Involved in 123 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline an alcohol Identifier CHEBI:30879 Charge 0 Formula HOR SMILEShelp_outline O[*] 2D coordinates Mol file for the small molecule Search links Involved in 1,506 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
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Namehelp_outline
S-hydroxy-L-cysteinyl-[protein]
Identifier
RHEA-COMP:17193
Reactive part
help_outline
- Name help_outline S-hydroxy-L-cysteine residue Identifier CHEBI:61973 Charge 0 Formula C3H5NO2S SMILEShelp_outline C([C@H](CSO)N*)(=O)* 2D coordinates Mol file for the small molecule Search links Involved in 2 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
Cross-references
RHEA:67124 | RHEA:67125 | RHEA:67126 | RHEA:67127 | |
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Reaction direction help_outline | undefined | left-to-right | right-to-left | bidirectional |
UniProtKB help_outline |
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Publications
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Janus-faced Sestrin2 controls ROS and mTOR signalling through two separate functional domains.
Kim H., An S., Ro S.H., Teixeira F., Jin Park G., Kim C., Cho C.S., Kim J.S., Jakob U., Lee J.H., Cho U.S.
Sestrins are stress-inducible metabolic regulators with two seemingly unrelated but physiologically important functions: reduction of reactive oxygen species (ROS) and inhibition of the mechanistic target of rapamycin complex 1 (mTORC1). How Sestrins fulfil this dual role has remained elusive so f ... >> More
Sestrins are stress-inducible metabolic regulators with two seemingly unrelated but physiologically important functions: reduction of reactive oxygen species (ROS) and inhibition of the mechanistic target of rapamycin complex 1 (mTORC1). How Sestrins fulfil this dual role has remained elusive so far. Here we report the crystal structure of human Sestrin2 (hSesn2), and show that hSesn2 is twofold pseudo-symmetric with two globular subdomains, which are structurally similar but functionally distinct from each other. While the N-terminal domain (Sesn-A) reduces alkylhydroperoxide radicals through its helix-turn-helix oxidoreductase motif, the C-terminal domain (Sesn-C) modified this motif to accommodate physical interaction with GATOR2 and subsequent inhibition of mTORC1. These findings clarify the molecular mechanism of how Sestrins can attenuate degenerative processes such as aging and diabetes by acting as a simultaneous inhibitor of ROS accumulation and mTORC1 activation. << Less