Reaction participants Show >> << Hide
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Namehelp_outline
[protein]-C-terminal L-amino acid-glycyl-phosphatidylserine
Identifier
RHEA-COMP:17326
Reactive part
help_outline
- Name help_outline C-terminal L-amino acid-(phosphatidylserine)-amidated glycine residue Identifier CHEBI:172942 Charge -2 Formula C12H14N3O12PR3 SMILEShelp_outline O(P(=O)(OC[C@@H](C([O-])=O)NC(CNC(=O)[C@@H](N*)*)=O)[O-])C[C@H](OC(*)=O)COC(*)=O 2D coordinates Mol file for the small molecule Search links Involved in 2 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline H2O Identifier CHEBI:15377 (Beilstein: 3587155; CAS: 7732-18-5) help_outline Charge 0 Formula H2O InChIKeyhelp_outline XLYOFNOQVPJJNP-UHFFFAOYSA-N SMILEShelp_outline [H]O[H] 2D coordinates Mol file for the small molecule Search links Involved in 6,048 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
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Namehelp_outline
[protein]-C-terminal L-amino acid-glycine
Identifier
RHEA-COMP:17324
Reactive part
help_outline
- Name help_outline C-terminal L-amino acid-glycine residue Identifier CHEBI:172940 Charge -1 Formula C4H5N2O3R SMILEShelp_outline *N[C@H](C(=O)NCC([O-])=O)* 2D coordinates Mol file for the small molecule Search links Involved in 2 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline a 1,2-diacyl-sn-glycero-3-phospho-L-serine Identifier CHEBI:57262 Charge -1 Formula C8H11NO10PR2 SMILEShelp_outline [NH3+][C@@H](COP([O-])(=O)OC[C@@H](COC([*])=O)OC([*])=O)C([O-])=O 2D coordinates Mol file for the small molecule Search links Involved in 43 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
Cross-references
| RHEA:67576 | RHEA:67577 | RHEA:67578 | RHEA:67579 | |
|---|---|---|---|---|
| Reaction direction help_outline | undefined | left-to-right | right-to-left | bidirectional |
| UniProtKB help_outline |
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Publications
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Non-canonical autophagy drives alternative ATG8 conjugation to phosphatidylserine.
Durgan J., Lystad A.H., Sloan K., Carlsson S.R., Wilson M.I., Marcassa E., Ulferts R., Webster J., Lopez-Clavijo A.F., Wakelam M.J., Beale R., Simonsen A., Oxley D., Florey O.
Autophagy is a fundamental catabolic process that uses a unique post-translational modification, the conjugation of ATG8 protein to phosphatidylethanolamine (PE). ATG8 lipidation also occurs during non-canonical autophagy, a parallel pathway involving conjugation of ATG8 to single membranes (CASM) ... >> More
Autophagy is a fundamental catabolic process that uses a unique post-translational modification, the conjugation of ATG8 protein to phosphatidylethanolamine (PE). ATG8 lipidation also occurs during non-canonical autophagy, a parallel pathway involving conjugation of ATG8 to single membranes (CASM) at endolysosomal compartments, with key functions in immunity, vision, and neurobiology. It is widely assumed that CASM involves the same conjugation of ATG8 to PE, but this has not been formally tested. Here, we discover that all ATG8s can also undergo alternative lipidation to phosphatidylserine (PS) during CASM, induced pharmacologically, by LC3-associated phagocytosis or influenza A virus infection, in mammalian cells. Importantly, ATG8-PS and ATG8-PE adducts are differentially delipidated by the ATG4 family and bear different cellular dynamics, indicating significant molecular distinctions. These results provide important insights into autophagy signaling, revealing an alternative form of the hallmark ATG8 lipidation event. Furthermore, ATG8-PS provides a specific "molecular signature" for the non-canonical autophagy pathway. << Less
Mol. Cell 81:2031-2040(2021) [PubMed] [EuropePMC]
This publication is cited by 1 other entry.