Enzymes
| UniProtKB help_outline | 1,445 proteins |
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- Name help_outline (R)-4'-phosphopantetheine sulfonate Identifier CHEBI:177300 Charge -3 Formula C11H20N2O10PS InChIKeyhelp_outline USVKSSSBJQTIBQ-VIFPVBQESA-K SMILEShelp_outline S(CCNC(=O)CCNC(=O)[C@H](O)C(COP(=O)([O-])[O-])(C)C)(=O)(=O)[O-] 2D coordinates Mol file for the small molecule Search links Involved in 1 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline H2O Identifier CHEBI:15377 (CAS: 7732-18-5) help_outline Charge 0 Formula H2O InChIKeyhelp_outline XLYOFNOQVPJJNP-UHFFFAOYSA-N SMILEShelp_outline [H]O[H] 2D coordinates Mol file for the small molecule Search links Involved in 6,485 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline (R)-pantetheine sulfonate Identifier CHEBI:177301 Charge -1 Formula C11H21N2O7S InChIKeyhelp_outline PSAJPLNSWWYXDV-VIFPVBQESA-M SMILEShelp_outline S(CCNC(=O)CCNC(=O)[C@H](O)C(CO)(C)C)(=O)(=O)[O-] 2D coordinates Mol file for the small molecule Search links Involved in 1 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline phosphate Identifier CHEBI:43474 Charge -2 Formula HO4P InChIKeyhelp_outline NBIIXXVUZAFLBC-UHFFFAOYSA-L SMILEShelp_outline OP([O-])([O-])=O 2D coordinates Mol file for the small molecule Search links Involved in 1,029 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
Cross-references
| RHEA:68336 | RHEA:68337 | RHEA:68338 | RHEA:68339 | |
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| Reaction direction help_outline | undefined | left-to-right | right-to-left | bidirectional |
| UniProtKB help_outline |
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Publications
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A family of metal-dependent phosphatases implicated in metabolite damage-control.
Huang L., Khusnutdinova A., Nocek B., Brown G., Xu X., Cui H., Petit P., Flick R., Zallot R., Balmant K., Ziemak M.J., Shanklin J., de Crecy-Lagard V., Fiehn O., Gregory J.F. III, Joachimiak A., Savchenko A., Yakunin A.F., Hanson A.D.
DUF89 family proteins occur widely in both prokaryotes and eukaryotes, but their functions are unknown. Here we define three DUF89 subfamilies (I, II, and III), with subfamily II being split into stand-alone proteins and proteins fused to pantothenate kinase (PanK). We demonstrated that DUF89 prot ... >> More
DUF89 family proteins occur widely in both prokaryotes and eukaryotes, but their functions are unknown. Here we define three DUF89 subfamilies (I, II, and III), with subfamily II being split into stand-alone proteins and proteins fused to pantothenate kinase (PanK). We demonstrated that DUF89 proteins have metal-dependent phosphatase activity against reactive phosphoesters or their damaged forms, notably sugar phosphates (subfamilies II and III), phosphopantetheine and its S-sulfonate or sulfonate (subfamily II-PanK fusions), and nucleotides (subfamily I). Genetic and comparative genomic data strongly associated DUF89 genes with phosphoester metabolism. The crystal structure of the yeast (Saccharomyces cerevisiae) subfamily III protein YMR027W revealed a novel phosphatase active site with fructose 6-phosphate and Mg(2+) bound near conserved signature residues Asp254 and Asn255 that are critical for activity. These findings indicate that DUF89 proteins are previously unrecognized hydrolases whose characteristic in vivo function is to limit potentially harmful buildups of normal or damaged phosphometabolites. << Less
Nat. Chem. Biol. 12:621-627(2016) [PubMed] [EuropePMC]
This publication is cited by 4 other entries.