Enzymes
| UniProtKB help_outline | 902 proteins |
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- Name help_outline 2-oxoadipate Identifier CHEBI:57499 Charge -2 Formula C6H6O5 InChIKeyhelp_outline FGSBNBBHOZHUBO-UHFFFAOYSA-L SMILEShelp_outline [O-]C(=O)CCCC(=O)C([O-])=O 2D coordinates Mol file for the small molecule Search links Involved in 11 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline L-kynurenine Identifier CHEBI:57959 Charge 0 Formula C10H12N2O3 InChIKeyhelp_outline YGPSJZOEDVAXAB-QMMMGPOBSA-N SMILEShelp_outline Nc1ccccc1C(=O)C[C@H]([NH3+])C([O-])=O 2D coordinates Mol file for the small molecule Search links Involved in 34 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline L-2-aminoadipate Identifier CHEBI:58672 Charge -1 Formula C6H10NO4 InChIKeyhelp_outline OYIFNHCXNCRBQI-BYPYZUCNSA-M SMILEShelp_outline [NH3+][C@@H](CCCC([O-])=O)C([O-])=O 2D coordinates Mol file for the small molecule Search links Involved in 15 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline kynurenate Identifier CHEBI:58454 Charge -1 Formula C10H6NO3 InChIKeyhelp_outline HCZHHEIFKROPDY-UHFFFAOYSA-M SMILEShelp_outline Oc1cc(nc2ccccc12)C([O-])=O 2D coordinates Mol file for the small molecule Search links Involved in 19 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline H2O Identifier CHEBI:15377 (CAS: 7732-18-5) help_outline Charge 0 Formula H2O InChIKeyhelp_outline XLYOFNOQVPJJNP-UHFFFAOYSA-N SMILEShelp_outline [H]O[H] 2D coordinates Mol file for the small molecule Search links Involved in 6,485 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
Cross-references
| RHEA:70047 | RHEA:70048 | RHEA:70049 | RHEA:70050 | |
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| Reaction direction help_outline | undefined | left-to-right | right-to-left | bidirectional |
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Publications
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Cloning and functional expression of a soluble form of kynurenine/alpha-aminoadipate aminotransferase from rat kidney.
Buchli R., Alberati-Giani D., Malherbe P., Koehler C., Broger C., Cesura A.M.
Several aminotransferases with kynurenine aminotransferase (KAT) activity are able to convert L-kynurenine into kynurenic acid, a putative endogenous modulator of glutamatergic neurotransmission. In the rat, one of the described KAT isoforms has been found to correspond to glutamine transaminase K ... >> More
Several aminotransferases with kynurenine aminotransferase (KAT) activity are able to convert L-kynurenine into kynurenic acid, a putative endogenous modulator of glutamatergic neurotransmission. In the rat, one of the described KAT isoforms has been found to correspond to glutamine transaminase K. In addition, rat kidney alpha-aminoadipate aminotransferase (AadAT) also shows KAT activity. In this report, we describe the isolation of a cDNA clone encoding the soluble form of this aminotransferase isoenzyme from rat (KAT/AadAT). Degenerate oligonucleotides were designed from the amino acid sequences of rat kidney KAT/AadAT tryptic peptides for use as primers for reverse transcription-polymerase chain reaction of rat kidney RNA. The resulting polymerase chain reaction fragment was used to screen a rat kidney cDNA library and to isolate a cDNA clone encoding KAT/AadAT. Analysis of the combined DNA sequences indicated the presence of a single 1275-base pair open reading frame coding for a soluble protein of 425 amino acid residues. KAT/AadAT appears to be structurally homologous to aspartate aminotransferase in the pyridoxal 5'-phosphate binding domain. RNA blot analysis of rat tissues, including brain, revealed a single species of KAT/AadAT mRNA of approximately 2.1 kilobases. HEK-293 cells transfected with the KAT/AadAT cDNA exhibited both KAT and AadAT activities with enzymatic properties similar to those reported for the rat native protein. << Less
J. Biol. Chem. 270:29330-29335(1995) [PubMed] [EuropePMC]
This publication is cited by 8 other entries.
Comments
Multi-step reaction: RHEA:70051 and RHEA:42452