Enzymes
| UniProtKB help_outline | 1 proteins |
| GO Molecular Function help_outline |
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- Name help_outline dopaminechrome Identifier CHEBI:189002 (CAS: 67992-45-4) help_outline Charge 0 Formula C8H7NO2 InChIKeyhelp_outline XDEURYRPQDIBSL-UHFFFAOYSA-N SMILEShelp_outline O=C1C=C2CCNC2=CC1=O 2D coordinates Mol file for the small molecule Search links Involved in 1 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline 5,6-dihydroxyindole Identifier CHEBI:27404 (CAS: 3131-52-0) help_outline Charge 0 Formula C8H7NO2 InChIKeyhelp_outline SGNZYJXNUURYCH-UHFFFAOYSA-N SMILEShelp_outline Oc1cc2cc[nH]c2cc1O 2D coordinates Mol file for the small molecule Search links Involved in 3 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
Cross-references
| RHEA:70199 | RHEA:70200 | RHEA:70201 | RHEA:70202 | |
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| Reaction direction help_outline | undefined | left-to-right | right-to-left | bidirectional |
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| Gene Ontology help_outline |
Publications
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Drosophila yellow-h encodes dopaminechrome tautomerase: A new enzyme in the eumelanin biosynthetic pathway.
Barek H., Zhao H., Heath K., Veraksa A., Sugumaran M.
Melanin is a widely distributed phenolic pigment that is biosynthesized from tyrosine and its hydroxylated product, dopa, in all animals. However, recent studies reveal a significant deviation from this paradigm, as insects appear to use dopamine rather than dopa as the major precursor of melanin. ... >> More
Melanin is a widely distributed phenolic pigment that is biosynthesized from tyrosine and its hydroxylated product, dopa, in all animals. However, recent studies reveal a significant deviation from this paradigm, as insects appear to use dopamine rather than dopa as the major precursor of melanin. This observation calls for a reconsideration of the insect melanogenic pathway. While phenoloxidases and laccases can oxidize dopamine for dopaminechrome production, the fate of dopaminechrome remains undetermined. Dopachrome decarboxylase/tautomerase, encoded by yellow-f/f2 of Drosophila melanogaster, can convert dopaminechrome into 5,6-dihydroxyindole, but the same enzyme from other organisms does not act on dopaminechrome, suggesting the existence of a specific dopaminechrome tautomerase (DPT). We now report the identification of this novel enzyme that biosynthesizes 5,6-dihydroxyindole from dopaminechrome in Drosophila. Dopaminechrome tautomerase acted on both dopaminechrome and N-methyl dopaminechrome but not on dopachrome or other aminochromes tested. Our biochemical and molecular studies reveal that this enzyme is encoded by the yellow-h gene, a member of the yellow gene family, and advance our understanding of the physiological functions of this gene family. Identification and characterization of DPT clarifies the precursor for melanin biosynthetic pathways and proves the existence of an independent melanogenic pathway in insects that utilizes dopamine as the primary precursor. << Less
Pigment Cell Melanoma Res. 35:26-37(2022) [PubMed] [EuropePMC]
This publication is cited by 1 other entry.