Enzymes
| UniProtKB help_outline | 127 proteins |
Reaction participants Show >> << Hide
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Namehelp_outline
N-terminal L-cysteinyl-[protein]
Identifier
RHEA-COMP:12707
Reactive part
help_outline
- Name help_outline N-terminal L-cysteine residue Identifier CHEBI:65250 Charge 1 Formula C3H7NOS SMILEShelp_outline C([C@H](CS)[NH3+])(=O)* 2D coordinates Mol file for the small molecule Search links Involved in 5 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline O2 Identifier CHEBI:15379 (CAS: 7782-44-7) help_outline Charge 0 Formula O2 InChIKeyhelp_outline MYMOFIZGZYHOMD-UHFFFAOYSA-N SMILEShelp_outline O=O 2D coordinates Mol file for the small molecule Search links Involved in 2,851 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
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Namehelp_outline
N-terminal S-hydroxy-S-oxy-L-cysteinyl-[protein]
Identifier
RHEA-COMP:17973
Reactive part
help_outline
- Name help_outline N-terminal S-hydroxy-S-oxo-L-cysteine residue Identifier CHEBI:156254 Charge 0 Formula C3H6NO3S SMILEShelp_outline C([C@H](CS([O-])=O)[NH3+])(=O)* 2D coordinates Mol file for the small molecule Search links Involved in 1 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline H+ Identifier CHEBI:15378 Charge 1 Formula H InChIKeyhelp_outline GPRLSGONYQIRFK-UHFFFAOYSA-N SMILEShelp_outline [H+] 2D coordinates Mol file for the small molecule Search links Involved in 9,932 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
Cross-references
| RHEA:70895 | RHEA:70896 | RHEA:70897 | RHEA:70898 | |
|---|---|---|---|---|
| Reaction direction help_outline | undefined | left-to-right | right-to-left | bidirectional |
| UniProtKB help_outline |
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Publications
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Conserved N-terminal cysteine dioxygenases transduce responses to hypoxia in animals and plants.
Masson N., Keeley T.P., Giuntoli B., White M.D., Puerta M.L., Perata P., Hopkinson R.J., Flashman E., Licausi F., Ratcliffe P.J.
Organisms must respond to hypoxia to preserve oxygen homeostasis. We identify a thiol oxidase, previously assigned as cysteamine (2-aminoethanethiol) dioxygenase (ADO), as a low oxygen affinity (high-<i>K</i> <sub>m</sub>O<sub>2</sub>) amino-terminal cysteine dioxygenase that transduces the oxygen ... >> More
Organisms must respond to hypoxia to preserve oxygen homeostasis. We identify a thiol oxidase, previously assigned as cysteamine (2-aminoethanethiol) dioxygenase (ADO), as a low oxygen affinity (high-<i>K</i> <sub>m</sub>O<sub>2</sub>) amino-terminal cysteine dioxygenase that transduces the oxygen-regulated stability of proteins by the N-degron pathway in human cells. ADO catalyzes the conversion of amino-terminal cysteine to cysteine sulfinic acid and is related to the plant cysteine oxidases that mediate responses to hypoxia by an identical posttranslational modification. We show in human cells that ADO regulates RGS4/5 (regulator of G protein signaling) N-degron substrates, modulates G protein-coupled calcium ion signals and mitogen-activated protein kinase activity, and that its activity extends to other N-cysteine proteins including the angiogenic cytokine interleukin-32. Identification of a conserved enzymatic oxygen sensor in multicellular eukaryotes opens routes to better understanding and therapeutic targeting of adaptive responses to hypoxia. << Less